| Immunological modes of pregnancy loss. | |
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MedLine Citation:
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PMID: 20367626 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During the implantation period, a significant portion of embryos are lost and eventually less than half of clinically established pregnancies end as full-term pregnancies without obstetrical complications. A significant portion of these pregnancy losses is associated with immune etiologies, including autoimmune and cellular immune abnormalities. Although an autoimmune etiology such as anti-phospholipid antibodies (APAs) has been reported to induce placental infarct and thrombosis at maternal-fetal interface, APAs induce inflammatory immune responses as well. Inflammatory immune responses, such as increased proportions of NK cells and Th1/Th2 cell ratios in peripheral blood are related to recurrent pregnancy losses and multiple implantation failures. Systemic and local inflammatory immune responses seem to be induced by activation of Toll-like receptors with infectious agents, fetal cell debris, or gonadotropin-releasing hormone agonist, etc. Cellular activation of T and NK cells leads to pro-inflammatory cytokine storm and consequently, placental infarction and thrombosis. Potential application of anti-inflammatory therapeutic agents for the prevention of pregnancy losses should be explored further. |
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Authors:
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Joanne Kwak-Kim; Joon Cheol Park; Hyun Kyong Ahn; Joon Woo Kim; Alice Gilman-Sachs |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-03-29 |
Journal Detail:
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Title: American journal of reproductive immunology (New York, N.Y. : 1989) Volume: 63 ISSN: 1600-0897 ISO Abbreviation: Am. J. Reprod. Immunol. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-22 Completed Date: 2010-10-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8912860 Medline TA: Am J Reprod Immunol Country: Denmark |
Other Details:
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Languages: eng Pagination: 611-23 Citation Subset: IM |
Affiliation:
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Reproductive Medicine Program, Department of Obstetrics and Gynecology, The Chicago Medical School at Rosalind Franklin University of Medicine and Science, Vernon Hills, IL, USA. joanne.kwakkim@rosalindfranklin.edu |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Coagulation Disorders / complications, immunology Embryo Implantation / immunology Embryo Loss / etiology*, immunology* Female Humans Inflammation / complications, immunology Killer Cells, Natural / immunology Male Mice Mice, Inbred Strains Pregnancy T-Lymphocytes, Helper-Inducer / immunology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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