| Immunological investigation of the hepatic tissue from infants with biliary atresia. | |
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MedLine Citation:
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PMID: 19089432 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Matrix metalloproteinases (MMPs) and their endogenous tissue inhibitors [tissue inhibitors of metalloproteinases (TIMPs)] have been implicated in tissue injury and remodeling in many organs. The objective of this study was to evaluate the expression of MMP-3 and -9, and TIMP-1, -2, and -3 and their relationship to liver fibrosis in infants with biliary atresia. METHODS: The expression of MMP-3 and-9 and TIMP-1, -2 and -3 was investigated in liver tissue samples of nine patients with biliary atresia. In addition, the expression of CCR-4 and CCR-5 was analyzed to investigate the activation of Th1 and Th2 cells. The mRNA levels were measured by semiquantitative reverse transcriptase polymerase chain reaction. RESULTS: The expression of MMP-3 was higher than that of MMP-9 in all samples (P < 0.01). The expression of TIMP-1 was higher than that of TIMP-2 and -3 in all samples (P < 0.01). The expression of CCR-5 was higher than that of CCR-4 (P < 0.05), which implied higher activation of Th1 cells relative to Th2 cells. CONCLUSION: Our findings suggest that MMP-3, possibly induced by Th1 cytokines, and its balance with TIMP-1, may be one of the factors involved in the pathogenesis of biliary atresia. |
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Authors:
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Haruna Baba; Yoshikazu Ohtsuka; Tohru Fujii; Hidenori Haruna; Satoru Nagata; Hiroyuki Kobayashi; Atsuyuki Yamataka; Toshiaki Shimizu; Takeshi Miyano; Yuichiro Yamashiro |
Publication Detail:
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Type: Journal Article Date: 2008-12-17 |
Journal Detail:
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Title: Pediatric surgery international Volume: 25 ISSN: 1437-9813 ISO Abbreviation: Pediatr. Surg. Int. Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-01-23 Completed Date: 2009-08-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8609169 Medline TA: Pediatr Surg Int Country: Germany |
Other Details:
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Languages: eng Pagination: 157-62 Citation Subset: IM |
Affiliation:
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Department of Pediatrics and Adolescence Medicine, Juntendo University School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biliary Atresia
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complications,
immunology* Female Humans Infant Infant, Newborn Liver / immunology* Liver Cirrhosis / immunology*, metabolism Male Matrix Metalloproteinase 3 / biosynthesis Matrix Metalloproteinase 9 / biosynthesis Receptors, CCR4 / biosynthesis Receptors, CCR5 / biosynthesis Tissue Inhibitor of Metalloproteinases / biosynthesis |
| Chemical | |
Reg. No./Substance:
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0/Receptors, CCR4; 0/Receptors, CCR5; 0/Tissue Inhibitor of Metalloproteinases; EC 3.4.24.17/Matrix Metalloproteinase 3; EC 3.4.24.35/Matrix Metalloproteinase 9 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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