Document Detail

Immunological indicators of coeliac disease activity are not altered by long-term oats challenge.
MedLine Citation:
PMID:  23379438     Owner:  NLM     Status:  MEDLINE    
Coeliac disease is a gluten-sensitive enteropathy that develops in genetically susceptible individuals. The disease exhibits many features of an autoimmune disorder. These include the production of highly specific anti-endomysial autoantibodies directed against the enzyme tissue transglutaminase. It is well accepted that wheat-, barley- and rye-based foods should be excluded in the gluten-free diet. Although several studies report that oats ingestion is safe in this diet, the potential toxicity of oats remains controversial. In the current study, 46 coeliac patients ingested oats for 1 year and were investigated for a potential immunogenic or toxic effect. Stringent clinical monitoring of these patients was performed and none experienced adverse effects, despite ingestion of a mean of 286 g of oats each week. Routine histological analysis of intestinal biopsies showed improvement or no change in 95% of the samples examined. Furthermore, tissue transglutaminase expression in biopsy samples, determined quantitatively using the IN Cell Analyzer, was unchanged. Employing immunohistochemistry, oats ingestion was not associated with changes in intraepithelial lymphocyte numbers or with enterocyte proliferation as assessed by Ki-67 staining. Finally, despite the potential for tissue transglutaminase to interact with oats, neither endomysial nor tissue transglutaminase antibodies were generated in any of the patients throughout the study. To conclude, this study reaffirms the lack of oats immunogenicity and toxicity to coeliac patients. It also suggests that the antigenic stimulus caused by wheat exposure differs fundamentally from that caused by oats.
S E J Cooper; N P Kennedy; B M Mohamed; M Abuzakouk; J Dunne; G Byrne; G McDonald; A Davies; C Edwards; J Kelly; C F Feighery
Related Documents :
23105578 - Lipid peroxidation and antioxidant status in blood of rheumatoid arthritis patients.
23071878 - How predictive are the signs and symptoms of small bowel obstruction.
23599328 - Reduction in blood glutathione levels occurs similarly in patients with primary-open an...
23190248 - Hepatocellular carcinoma in uremic patients: is there evidence for an increased risk of...
8841308 - Ocular malaria. a clinical and histopathologic study.
1621498 - Endocrine function in multiple sclerosis.
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  171     ISSN:  1365-2249     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-05     Completed Date:  2013-04-02     Revised Date:  2014-03-06    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  313-8     Citation Subset:  IM    
Copyright Information:
© 2012 British Society for Immunology.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Autoantibodies / biosynthesis
Avena sativa / adverse effects,  immunology*
Celiac Disease / immunology*
Diet, Gluten-Free
Fluorescent Antibody Technique
GTP-Binding Proteins / immunology
Ki-67 Antigen / analysis
Middle Aged
Transglutaminases / immunology
Reg. No./Substance:
0/Autoantibodies; 0/Ki-67 Antigen; EC 2.3.2.-/transglutaminase 2; EC; EC 3.6.1.-/GTP-Binding Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The correlation between T helper type 17 cells and clinical characters in Chinese paediatric patient...
Next Document:  Differential effect of hyperglycaemia on the immune response in an experimental model of diabetes in...