Document Detail

Immunological findings in whole and parotid saliva of patients with Crohn's disease and healthy controls.
MedLine Citation:
PMID:  6499626     Owner:  NLM     Status:  MEDLINE    
Since oral lesions appear to occur more commonly in patients with Crohn's disease (CD) than in normal controls or patients with ulcerative colitis, it has been suggested that a deficit of locally produced IgA allows the invasion of the oral mucous membrane by antigens and contributes to the production of oral lesions. In connection with this hypothesis, the concentrations of IgA, IgM, and IgG in whole and parotid saliva were investigated by the ELISA technique in 20 patients with CD and 20 healthy subjects matched for dental status. IgA predominated in whole and parotid saliva in both patients and controls, and in both groups whole saliva had higher levels of IgA, IgM, and IgG than parotid saliva did. Compared with the controls, IgA, IgM, and IgG levels were significantly elevated in the whole saliva of CD patients. However, no correlation was found between immunoglobulin levels and age, sex, therapy, duration, localization, or activity of the disease.
G Crama-Bohbouth; P Lems-van Kan; I T Weterman; I Biemond; A S Peña
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  29     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  1984 Dec 
Date Detail:
Created Date:  1985-01-18     Completed Date:  1985-01-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1089-92     Citation Subset:  AIM; IM    
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MeSH Terms
Crohn Disease / immunology*
Enzyme-Linked Immunosorbent Assay
Immunoglobulin A / analysis
Immunoglobulin M / analysis
Middle Aged
Parotid Gland / immunology*
Saliva / immunology*
Reg. No./Substance:
0/Immunoglobulin A; 0/Immunoglobulin M

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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