| Immunological findings in hemp workers. | |
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MedLine Citation:
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PMID: 1464288 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Immunological status and its relation to respiratory findings were studied in 42 female textile workers occupationally exposed to hemp dust and in 49 female control workers. Skin prick tests with hemp or flax dust extracts from different parts of the mill in hemp workers demonstrated the following frequencies of positive tests to antigens: a mixture of hemp and flax extracts (64%), followed by flax extracts (48%), hemp from combing machines (41%), hemp from carding machines (38%), hemp from spinning and weaving machines (33%), and hemp from softening machines (20%). The prevalence of positive skin tests to hemp or flax allergens in control workers was consistently lower, ranging from 21 to 5%. Increased total serum IgE was recorded in 35.7% of hemp workers compared to only 5.0% of control workers (P < 0.05). Hemp workers with positive skin tests had significantly higher prevalences of chronic respiratory symptoms than those with negative skin tests. There were, however, no differences for acute symptoms between workers with positive and negative skin tests. Across-shift changes and baseline lung function were not different when compared by immunologic status. We showed additionally that a water-soluble extract of hemp dust causes a dose-related contraction of nonsensitized guinea pig tracheal smooth muscle when studied in vitro. Our results suggest that frequent immunologic abnormalities can be documented in hemp workers but, with the exception of chronic respiratory symptoms, in general, these do not correlate with respiratory findings. |
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Authors:
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E Zuskin; B Kanceljak; E N Schachter; T J Witek; S Maayani; S Goswami; Z Marom; N Rienzi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Environmental research Volume: 59 ISSN: 0013-9351 ISO Abbreviation: Environ. Res. Publication Date: 1992 Dec |
Date Detail:
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Created Date: 1993-01-19 Completed Date: 1993-01-19 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0147621 Medline TA: Environ Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 350-61 Citation Subset: IM |
Affiliation:
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Andrija Stampar School of Public Health, Zagreb, Croatia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Animals Byssinosis / epidemiology, immunology Cannabis* Croatia Dust / adverse effects* Female Guinea Pigs Humans Immunoglobulin E / blood Middle Aged Muscle Contraction Muscle, Smooth / physiopathology Occupational Diseases / epidemiology, immunology* Pharynx / microbiology Prevalence Respiratory Function Tests Respiratory Tract Diseases / epidemiology, immunology Skin Tests Textile Industry* Trachea |
| Grant Support | |
ID/Acronym/Agency:
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R01-OHO 2593-O1A1/OH/NIOSH CDC HHS; YF 733//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Dust; 37341-29-0/Immunoglobulin E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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