| Immunological features of primary anti-phospholipid syndrome in connection with endothelial dysfunction. | |
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MedLine Citation:
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PMID: 18782854 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To describe how certain peripheral immune parameters reflect the inflammatory alterations in patients with primary APS. METHODS: Twenty-eight patients with newly diagnosed primary APS were studied. The control group included 26 patients with stable coronary disease and 38 healthy individuals. Peripheral blood lymphocyte subgroups were quantified, intracellular cytokines were measured by flow cytometry, soluble cytokines and auto-antibodies were assessed using ELISA. Endothelial dysfunction was evaluated by measuring endothelium-dependent (flow-mediated; FMD) vasodilation. Carotid duplex ultrasound was performed to quantify the carotid artery intima-media thickness (IMT). Stiffness parameters, augmentation index (AIx) and pulse wave velocity (PWV) were assessed by TensioClinic technology. RESULTS: Serum IL-4 and IL-6 levels were significantly higher in APS. CD4+IL10+ and CD8+IL10+ cell percentages in APS were significantly increased compared with controls. Th 0 and T cytotoxic 0 cell percentages were significantly decreased in patients compared with controls. FMD in APS was significantly lower, while IMT was higher than that of controls. FMD showed strong association with stiffness parameters, AIx and PWV. A significant negative linear correlation was detected between PWV and CD8+IL10+ cell percentages and significant positive linear correlation was found between PWV and CD8+IL10- cell percentage. CONCLUSION: In APS, the orchestrated pro-inflammatory cascade can eventually result in endothelial dysfunction, leading to the characteristic vascular abnormalities of the disease. |
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Authors:
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P Soltesz; H Der; K Veres; R Laczik; S Sipka; G Szegedi; P Szodoray |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2008-09-09 |
Journal Detail:
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Title: Rheumatology (Oxford, England) Volume: 47 ISSN: 1462-0332 ISO Abbreviation: Rheumatology (Oxford) Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-10-17 Completed Date: 2008-12-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883501 Medline TA: Rheumatology (Oxford) Country: England |
Other Details:
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Languages: eng Pagination: 1628-34 Citation Subset: AIM; IM |
Affiliation:
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Third Department of Medicine, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antiphospholipid Syndrome
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immunology*,
physiopathology,
ultrasonography Biological Markers / blood Blood Flow Velocity CD4-Positive T-Lymphocytes / immunology CD8-Positive T-Lymphocytes / immunology Carotid Arteries / physiopathology, ultrasonography Case-Control Studies Coronary Artery Disease / ultrasonography Elasticity Endothelium, Vascular / immunology*, physiopathology, ultrasonography Female Flow Cytometry Humans Interferon-gamma / blood Interleukin-10 / blood Interleukin-4 / blood Interleukin-6 / blood Lymphocyte Activation Lymphocyte Count Male Statistics, Nonparametric Tunica Intima / ultrasonography Ultrasonography, Doppler, Duplex Vascular Diseases / immunology*, physiopathology, ultrasonography Vasodilation |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Interleukin-6; 130068-27-8/Interleukin-10; 207137-56-2/Interleukin-4; 82115-62-6/Interferon-gamma |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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