| Immunological changes in patients with primary osteoarthritis of the hip after total joint replacement. | |
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MedLine Citation:
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PMID: 12892206 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We aimed to assess whether the immunological abnormalities which have been observed in patients with loose total hip replacements (THRs) are present in patients with a well-fixed prosthesis. We examined blood samples from 39 healthy donors, 22 patients before THR and 41 with well-fixed THRs of different types (15 metal-on-metal, 13 metal-on-polyethylene, 13 ceramic-on-ceramic). Before THR, the patients showed a decrease in leukocytes and myeloid cells in comparison with healthy donors, and a prevalence of type-1 T lymphocytes, which was confirmed by the increase in ratio of interferon-gamma to interleukin 4. Moreover, patients with metal-on-metal or metal-on-polyethylene implants showed a significant decrease in the number of T lymphocytes and a significant increase in the serum level of chromium and cobalt, although no significant correlation was observed with the immunological changes. In the ceramic-on-ceramic group, leukocytes and lymphocyte subsets were not significantly changed, but a significant increase in type-2 cytokines restored the ratio of interferon-gamma to interleukin 4 to normal values. We conclude that abnormalities of the cell-mediated immune response may be present in patients with a well-fixed THR, and that the immunological changes are more evident in those who have at least one metal component in the articular coupling. |
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Authors:
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Donatella Granchi; Lucia Savarino; Gabriela Ciapetti; Elisabetta Cenni; Roberto Rotini; Michele Mieti; Nicola Baldini; Armando Giunti |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of bone and joint surgery. British volume Volume: 85 ISSN: 0301-620X ISO Abbreviation: J Bone Joint Surg Br Publication Date: 2003 Jul |
Date Detail:
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Created Date: 2003-08-01 Completed Date: 2003-08-28 Revised Date: 2010-11-10 |
Medline Journal Info:
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Nlm Unique ID: 0375355 Medline TA: J Bone Joint Surg Br Country: England |
Other Details:
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Languages: eng Pagination: 758-64 Citation Subset: AIM; IM |
Affiliation:
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Laboratorio dei Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Bologna, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antigens, CD / blood Arthroplasty, Replacement, Hip* B-Lymphocytes / immunology Ceramics Female Humans Immunity, Cellular / immunology Leukocytes / immunology Male Metals / blood Middle Aged Myeloid Cells / immunology Osteoarthritis, Hip / immunology* Phytohemagglutinins / immunology Polyethylene / immunology T-Lymphocytes / immunology |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/Ceramics; 0/Metals; 0/Phytohemagglutinins; 9002-88-4/Polyethylene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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