Document Detail


Immunological changes in normal pregnancy.
MedLine Citation:
PMID:  1563567     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During pregnancy the mother must tolerate intra-uterine allogenic fetal tissue. Failure of this tolerance may cause spontaneous abortion. The immunological changes occurring in normal pregnancy are poorly understood. The aim of this study was to investigate the immunological changes occurring in pregnancy. Thirty women in the first trimester; 10 in the second and 10 in the third trimester of pregnancy were studied and compared to age matched non-pregnant controls. In normal pregnancy there was an increase in the total white cell count with no change in the lymphocyte count. There was a fall in total T cell numbers and activated T cell numbers, with no change in helper/inducer or suppressor/cytotoxic T cell numbers. [3H]Thymidine uptake in response to three different mitogens was increased. This implies an increase in potential for the cells to respond to mitogens. There was no change in interleukin-2 receptor levels, suggesting that despite this increased potential there was no general activation of the immune system. A rise in IgM and IgG was found after mitogen stimulation of peripheral blood lymphocytes, suggesting an increase in potential antibody production. These results demonstrate that lymphocytes from pregnant women have an increased potential rather than an increased activity.
Authors:
M A MacLean; R Wilson; J A Thomson; S Krishnamurthy; J J Walker
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  43     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-05-18     Completed Date:  1992-05-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  167-72     Citation Subset:  IM    
Affiliation:
Department of Obstetrics, University of Glasgow, U.K.
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MeSH Terms
Descriptor/Qualifier:
Female
Humans
Immunoglobulin G / biosynthesis
Immunoglobulin M / biosynthesis
Leukocyte Count
Lymphocyte Activation
Lymphocytes / cytology,  immunology
Mitogens / pharmacology
Pregnancy / immunology*
Receptors, Interleukin-2 / metabolism
T-Lymphocyte Subsets / cytology
Chemical
Reg. No./Substance:
0/Immunoglobulin G; 0/Immunoglobulin M; 0/Mitogens; 0/Receptors, Interleukin-2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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