Document Detail


Immunological aspects of pregnancy.
MedLine Citation:
PMID:  16487878     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Alterations to the immune status of the pregnant woman are necessary to allow mothers to tolerate genetically different fetal tissues during pregnancy. These alterations lead to impaired cell-mediated immunity with increased susceptibility to certain infections such as tuberculosis. During pregnancy, the maternal immune system also shows a relative bias toward T helper type 2 immunity. Several inflammatory dermatoses are either unique to pregnancy or altered by the pregnant state. Immunologists are now beginning to understand the various factors that contribute to the maternal immune tolerance and, in particular, the role of classic (human leukocyte antigen [HLA]-A, HLA-B, HLA-C, and HLA-D) and non-classic (HLA-E, HLA-F, and HLA-G) major histocompatability antigens in this process. Human leukocyte antigen-G, in particular, seems to be important in protecting HLA mismatched tissue from the innate immune system, and investigation of HLA-G expression may help to explain how pregnancy affects inflammatory skin disease. Immunologists are now beginning to understand the alterations to the immune status of the pregnant woman that are necessary to allow mothers to tolerate genetically different fetal tissues during pregnancy. These alterations may help to explain how pregnancy effects inflammatory skin disease.
Authors:
Leona Yip; James McCluskey; Rodney Sinclair
Related Documents :
7027548 - Major h-2 and non-h-2 differences between parental strains prevent occurrence of fetect...
6410918 - Oral desensitization in rh disease.
2254878 - Reduction in popliteal lymph node graft-versus-host reactivity by homologous and hetero...
1861098 - Peripartum cardiomyopathy: clinical and therapeutic characteristics.
22741098 - The impact of intrauterine tobacco exposure on the cerebral mass of the neonate based o...
17925088 - The effect of correlations between screening markers on screening performance.
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinics in dermatology     Volume:  24     ISSN:  0738-081X     ISO Abbreviation:  Clin. Dermatol.     Publication Date:    2006 Mar-Apr
Date Detail:
Created Date:  2006-02-20     Completed Date:  2006-05-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8406412     Medline TA:  Clin Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  84-7     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of Melbourne, 3010 Melbourne, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Female
HLA Antigens / immunology
Humans
Immune System / physiology*
Inflammation / immunology,  physiopathology
Pemphigoid Gestationis / immunology,  physiopathology
Pregnancy / immunology*
Pregnancy Complications / immunology,  physiopathology*
Psoriasis / immunology,  physiopathology
Skin Diseases / immunology,  physiopathology*
Chemical
Reg. No./Substance:
0/HLA Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Physiological and biological skin changes in pregnancy.
Next Document:  Metabolic diseases and pregnancy.