Document Detail

Immunological aspects of mammary tumors in dogs and cats: a survey including own studies and pertinent literature.
MedLine Citation:
PMID:  2264285     Owner:  NLM     Status:  MEDLINE    
Naturally occurring cancer in companion animals parallels cancer in man more closely than does experimentally induced cancer in inbred laboratory animals. In dogs and cats, as in man, a role for immune responses is indicated in the development of tumors. A survey is presented based on the literature and our own studies concerning the immunological and immunotherapeutic aspects of canine and feline mammary neoplasia. In dogs bearing mammary neoplasms, circulating immune complexes appear to play a negative role in the generation of effective antitumor immune responses. The functional role of peripheral blood lymphocytes and tumor-infiltrating lymphocytes in dogs and cats with mammary tumors is not yet fully established. No tumor antigen responsible for humoral or cellular responses has yet been identified. Extracorporeal perfusion of serum of dogs with mammary tumors and subcutaneous administration of mitomycin- and neuraminidase-treated autologous tumor cells are associated with improved prognosis. The opposite was true for i.v. treatment with BCG or Corynebacterium parvum vaccine in our study, in contrast to a previous report. A number of other treatment modalities in cats and dogs with mammary carcinomas failed to induce tumor regression. Canine and feline mammary carcinomas are good candidates for modern immunotherapeutic approaches.
V P Rutten; W Misdorp; A Gauthier; M Estrada; J P Mialot; A L Parodi; G R Rutteman; K Weyer
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Veterinary immunology and immunopathology     Volume:  26     ISSN:  0165-2427     ISO Abbreviation:  Vet. Immunol. Immunopathol.     Publication Date:  1990 Nov 
Date Detail:
Created Date:  1991-02-07     Completed Date:  1991-02-07     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8002006     Medline TA:  Vet Immunol Immunopathol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  211-25     Citation Subset:  IM    
Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, University of Utrecht, The Netherlands.
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MeSH Terms
Carcinoma / immunology*,  mortality,  therapy
Cat Diseases / immunology*,  mortality,  therapy
Dog Diseases / immunology*,  mortality,  therapy
Mammary Neoplasms, Animal / immunology*,  mortality,  therapy

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