| Immunological aspect of cardiac remodeling: T lymphocyte subsets in inflammation-mediated cardiac fibrosis. | |
| | |
MedLine Citation:
|
PMID: 20965166 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Cardiac fibrosis is defined as a progressive accumulation of fibrillar extracellular matrix (ECM) in the myocardium. The regulation of extracellular matrix remodeling is primarily mediated by cardiac fibroblasts (CF). Evidences suggest that various T lymphocyte phenotypes differentially affect organ fibrosis through modulating CF collagen and MMP/TIMP gene expression, MMP activity and cardiac collagen cross-linking, leading to altered ECM composition. In regard to the importance of cytokines in cardiac fibrosis and heart failure, in this review, we will address the role of different T cell subsets in inflammation-mediated cardiac fibrosis, from a distinct perspective of T cell and fibroblast interaction. We conclude that in addition to preventive strategies, therapies based on deviation of Th1/Th2 paradigm, and manipulation of Tregs and Th17 would show promising results in future studies. |
| | |
Authors:
|
Liu Wei |
Related Documents
:
|
3231066 - Serial changes in nuclear magnetic resonance relaxation times after myocardial infarcti... 17384136 - Preservation of coronary reserve by ivabradine-induced reduction in heart rate in infar... 11770086 - Myocardial enzymatic activity of renin and cathepsin d before and after bilateral nephr... 19904216 - Protective effect of dimethyl sulfoxide on acute myocardial infarction in rats. 9717016 - Prediction of behavioural and emotional problems in children and adolescents with opera... 9420726 - Technetium 94m-labeled methoxyisobutyl isonitrile: dosimetry and resting cardiac imagin... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-19 |
Journal Detail:
|
Title: Experimental and molecular pathology Volume: 90 ISSN: 1096-0945 ISO Abbreviation: Exp. Mol. Pathol. Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-01-03 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0370711 Medline TA: Exp Mol Pathol Country: United States |
Other Details:
|
Languages: eng Pagination: 74-8 Citation Subset: IM |
Copyright Information:
|
Crown Copyright © 2010. Published by Elsevier Inc. All rights reserved. |
Affiliation:
|
Department of Cardiology, First Affiliated Hospital of Harbin Medical University, 150001, China. wliu4@uvm.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The effect of S-nitrosoglutathione and L-cysteine on chloride efflux from cystic fibrosis airway epi...
Next Document: Community effect triggers terminal differentiation of myogenic cells derived from muscle satellite c...