Document Detail


Immunological Variation Between Inbred Laboratory Mouse Strains: Points to Consider in Phenotyping Genetically Immunomodified Mice.
MedLine Citation:
PMID:  22135019     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Inbred laboratory mouse strains are highly divergent in their immune response patterns as a result of genetic mutations and polymorphisms. The generation of genetically engineered mice (GEM) has, in the past, used embryonic stem (ES) cells for gene targeting from various 129 substrains followed by backcrossing into more fecund mouse strains. Although common inbred mice are considered "immune competent," many have variations in their immune system-some of which have been described-that may affect the phenotype. Recognition of these immune variations among commonly used inbred mouse strains is essential for the accurate interpretation of expected phenotypes or those that may arise unexpectedly. In GEM developed to study specific components of the immune system, accurate evaluation of immune responses must take into consideration not only the gene of interest but also how the background strain and microbial milieu contribute to the manifestation of findings in these mice. This article discusses points to consider regarding immunological differences between the common inbred laboratory mouse strains, particularly in their use as background strains in GEM.
Authors:
R S Sellers; C B Clifford; P M Treuting; C Brayton
Related Documents :
7592459 - Structural elucidation of the lipopolysaccharide core region of the o-chain-deficient m...
2425249 - A molecular model of artificial glycoprotein with predetermined multiple immunodetermin...
9352919 - Mutants of ralstonia (pseudomonas) solanacearum sensitive to antimicrobial peptides are...
12091099 - Galactose-containing polysaccharides from dictyostelium mucoroides as possible acceptor...
1089629 - Blocking of bacteriophages phi w and phi 5 with lipopolysaccharides from escherichia co...
14080799 - Extracellular polysaccharide of mucoid lactobacillus bifidus.
19136029 - Differentiation of cherry leaf roll virus isolates from various host plants by immunoca...
12474899 - Influence of myriophyllum spicatum-derived tannins on gut microbiota of its herbivore a...
9158799 - Molecular epidemiology of enterococci with high-level resistance to aminoglycosides.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-30
Journal Detail:
Title:  Veterinary pathology     Volume:  -     ISSN:  1544-2217     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-12-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0312020     Medline TA:  Vet Pathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  BMI and gender do not influence surgical accuracy during minimally invasive total hip arthroplasty.
Next Document:  Development, structure, and keratin expression in C57BL/6J mouse eccrine glands.