| Immunological response after therapeutic vaccination with WT1 mRNA-loaded dendritic cells in end-stage endometrial carcinoma. | |
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MedLine Citation:
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PMID: 20944158 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Wilms' tumour gene 1 (WT1), a highly ranked immunotherapeutic target, is expressed in uterine cancer and therefore WT1 immunotherapy may present an attractive treatment option. PATIENT AND METHODS: An HLA-A2.1-positive 46-year-old woman with end-stage serous endometrial cancer received 4 weekly injections of WT1-RNA-loaded dendritic cells. Response was measured clinically (CT scan), biochemically (CA125) and immunologically (WT1-specific T cells). RESULTS: The patient showed WT1 positivity in 10% of tumour cells and diffusely in the intratumoural endothelial cells of the recurrent disease. After 2 injections, CA125 started to decrease and WT1-specific T-cells increased 2.5-fold. The treatment was feasible and there were no treatment-related side-effects. However, the patient, suffering from diffuse disease which became progressive again, died 8 months later. CONCLUSION: This is the first patient with a WT1-positive endometrial carcinoma, to receive immunotherapy with WT1-RNA-loaded dendritic cells, resulting in a vaccine-specific T cell response. |
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Authors:
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Ann Coosemans; Matthias Wölfl; Zwi N Berneman; Viggo Van Tendeloo; Ignace Vergote; Frédéric Amant; Stefaan W Van Gool |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Anticancer research Volume: 30 ISSN: 1791-7530 ISO Abbreviation: Anticancer Res. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-10-14 Completed Date: 2010-11-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8102988 Medline TA: Anticancer Res Country: Greece |
Other Details:
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Languages: eng Pagination: 3709-14 Citation Subset: IM |
Affiliation:
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Department of Child and Women, UZ Gasthuisberg, Katholieke Universiteit Leuven, Belgium. an.coosemans@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cancer Vaccines
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immunology,
therapeutic use* Dendritic Cells / immunology* Endometrial Neoplasms / immunology, pathology, therapy* Female Humans Immunotherapy / methods* Middle Aged Neoplasm Recurrence, Local / therapy Neoplasm Staging RNA, Messenger / immunology T-Lymphocytes, Cytotoxic / immunology WT1 Proteins / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Cancer Vaccines; 0/RNA, Messenger; 0/WT1 Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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