| Immunologic and microbiologic profiles of chronic and aggressive periodontitis subjects. | |
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MedLine Citation:
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PMID: 20450404 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: This study determines the gingival crevicular fluid (GCF) levels of interleukin (IL)-1 beta, IL-2, IL-4, IL-8, interferon (IFN)-gamma and elastase activity in inflamed shallow and deep periodontal sites from patients with generalized chronic (GCP) and generalized aggressive periodontitis (GAgP), and to compare them to shallow sites from subjects with gingivitis. A secondary aim analyzes the microbiologic profile of these subjects. METHODS: Cross-sectional clinical data were obtained from 20 GCP, 17 GAgP, and 10 gingivitis subjects. GCF samples were collected with paper strips and the levels of IL-1 beta, IL-2, IL-4, IL-8, and IFN-gamma were measured using a multiplexed bead immunoassay. Elastase activity was assessed by an enzymatic assay. Subgingival plaque samples were analyzed using checkerboard DNA-DNA hybridization. Significance of differences among groups for immunologic and microbiologic data was examined using Kruskal-Wallis adjusting for multiple comparisons. RESULTS: Mean clinical parameters and GCF volumes were higher in patients with GCP and GAgP compared to the gingivitis group. Higher levels of IL-1 beta and higher elastase activity were found in deep sites compared to shallow sites in both periodontitis groups (P <0.05). The microbiologic data showed significantly higher levels of the red complex species in patients with GCP and GAgP compared to gingivitis (P <0.05). There were no statistically significant differences in levels of GCF biomarkers and in levels of subgingival bacterial species between subjects with GCP and GAgP. CONCLUSION: There were no statistically significant differences in the measured immunologic and microbiologic parameters between subjects with GCP and GAgP. |
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Authors:
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Bruno Rescala; Wilson Rosalem; Ricardo P Teles; Ricardo G Fischer; Anne D Haffajee; Sigmund S Socransky; Anders Gustafsson; Carlos Marcelo Figueredo |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of periodontology Volume: 81 ISSN: 1943-3670 ISO Abbreviation: J. Periodontol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-03 Completed Date: 2010-12-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8000345 Medline TA: J Periodontol Country: United States |
Other Details:
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Languages: eng Pagination: 1308-16 Citation Subset: D; IM |
Affiliation:
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Department of Periodontology, Rio de Janeiro State University - UERJ, Rio de Janeiro, Brazil. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aggressive Periodontitis / immunology*, microbiology* Analysis of Variance Biological Markers / metabolism Chronic Periodontitis / immunology*, microbiology* Cross-Sectional Studies Dental Plaque / microbiology Female Gingival Crevicular Fluid / chemistry Gingivitis / immunology, microbiology Humans Inflammation Mediators / metabolism* Interferon-gamma / metabolism Interleukins / metabolism Leukocyte Elastase / metabolism Male Nucleic Acid Hybridization Smoking Statistics, Nonparametric |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Inflammation Mediators; 0/Interleukins; 82115-62-6/Interferon-gamma; EC 3.4.21.37/Leukocyte Elastase |
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