Document Detail

Immunologic studies in patients with recurrent bronchopulmonary infections.
MedLine Citation:
PMID:  1079124     Owner:  NLM     Status:  MEDLINE    
In view of the known association of several different immune deficiency disorders with infections of the respiratory tract, a number of immunologic parameters were investigated in 15 patients with recurrent brochopulmonary infections. The patients' neutrophils all demonstrated normal intracellular killing of Staphylococcus aureus, and responded normally to chemotactic stimuli. Although assays of complement 3c were normal in all patients' sera, defective total hemolytic complement activity was consistently shown in 1 patinets manifested elevated serum immunoglobulin concentrations. Severe alpha1 -antitrypsin deficiency (Pi ZZ phenotype) was discovered in 1 patient. Three patients displayed cutaneous anergy to a battery of skin-test antigens, but lymphocytes from all patients studied responded normally to in vitro phytohemagglutinin stimulation. A "blocking" factor found in the serum of 3 patients suppressed the in bitro transformation of normal Candida-responsive lymphocytes by Candida albicans antigen. "Cold" lymphocytotoxins were detected in the sera of 10 patients, but in only 3 of 19 control sera. Although the significance of these findings is unknown, they may possibly have pathogenetic relevance in a small number of the patients studied.
E Kagan; C L Soskolne; S Zwi; S Hurwitz; G M Maier; T Ipp; A R Rabson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  111     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1975 Apr 
Date Detail:
Created Date:  1975-07-07     Completed Date:  1975-07-07     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  441-51     Citation Subset:  AIM; IM    
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MeSH Terms
Bronchiectasis / immunology
Candida / immunology
Cold Temperature
Complement System Proteins / analysis
Cytotoxicity Tests, Immunologic
Immunoglobulin A / analysis
Immunoglobulin G / analysis
Immunoglobulin M / analysis
Lymphocyte Activation
Middle Aged
Neutrophils / physiology
Pneumonia / immunology
Respiratory Tract Infections / immunology*
Skin Tests
Trypsin Inhibitors / blood
Tuberculin Test
Reg. No./Substance:
0/Immunoglobulin A; 0/Immunoglobulin G; 0/Immunoglobulin M; 0/Lymphotoxin-alpha; 0/Trypsin Inhibitors; 9007-36-7/Complement System Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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