| Immunologic response to fungus is not universally associated with chronic rhinosinusitis. | |
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MedLine Citation:
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PMID: 20974326 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the December 2009 issue of this journal, Orlandi et al presented a study in which peripheral blood mononuclear cells (PBMCs) from chronic rhinosinusitis (CRS) patients (5 from Texas, 5 from Utah) and seven nonhealthy controls were stimulated with fungal extracts. Despite the small numbers, they confirmed important aspects of previous studies: 1) CRS patients' PBMCs react to certain fungal stimuli by producing significantly (P < 0.05) higher amounts of interleukin (IL)-5 and IL-13 when compared to controls; 2) CRS patients have an enhanced humoral response (significantly elevated immunoglobulin [Ig] G levels to Alternaria); and 3) CRS patients react independently from an IgE-mediated allergy, as evidenced by that fact that nonallergic CRS patients also produced IL-5 in response to fungal stimuli. Unfortunately, the authors chose not to highlight their positive results. They emphasized what they failed to demonstrate, specifically an immune response to fungi above a certain threshold in some patients (Utah) with milder CRS. However, these results are potentially explained by the different methods used, and care should be applied when interpreting their results. |
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Authors:
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Jens U Ponikau; David A Sherris; Eugene B Kern |
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Publication Detail:
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Type: Comment; Journal Article; Review |
Journal Detail:
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Title: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery Volume: 143 ISSN: 1097-6817 ISO Abbreviation: Otolaryngol Head Neck Surg Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-26 Completed Date: 2010-11-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8508176 Medline TA: Otolaryngol Head Neck Surg Country: United States |
Other Details:
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Languages: eng Pagination: 607-10 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 American Academy of Otolaryngology–Head and Neck Surgery Foundation. Published by Mosby, Inc. All rights reserved. |
Affiliation:
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Department of Otorhinolaryngology, Gromo Institute & Sinus Center, University at Buffalo, The State University of New York, Buffalo, NY 14209, USA. jponikau@buffalo.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Chronic Disease Disease Progression Fungi / immunology*, isolation & purification Humans Immunity, Cellular* Immunoglobulin E / blood Immunoglobulin G / blood Interleukin-13 / biosynthesis Interleukin-5 / biosynthesis Monocytes / immunology*, metabolism Rhinitis / immunology*, metabolism, microbiology Sinusitis / immunology*, metabolism, microbiology |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin G; 0/Interleukin-13; 0/Interleukin-5; 37341-29-0/Immunoglobulin E |
| Comments/Corrections | |
Comment On:
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Otolaryngol Head Neck Surg. 2009 Dec;141(6):750-6.e1-2
[PMID:
19932849
]
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Comment In:
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Otolaryngol Head Neck Surg. 2010 Nov;143(5):611-3
[PMID:
20974327
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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