| Immunologic research in kidney ischemia/reperfusion injury at Johns Hopkins University. | |
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MedLine Citation:
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PMID: 20082154 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Kidney ischemia/reperfusion injury (IRI) is a common and serious problem in hospitalized patients. Immune cell trafficking and leukocyte-endothelial adhesion potentiate kidney IRI. An important immunomodulatory role of T lymphocytes has been elucidated in IRI. Regulatory T cells are a lymphocyte subset that has recently been demonstrated to perform a protective role both in early injury from IRI as well as in later repair. The immune system also participates in distant organ effects during kidney IRI. Studies focusing on immune aspects of kidney IRI have enabled the discovery of promising novel therapeutic and diagnostic approaches. |
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Authors:
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Gang Jee Ko; Asif Zakaria; Karl L Womer; Hamid Rabb |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Immunologic research Volume: 47 ISSN: 1559-0755 ISO Abbreviation: Immunol. Res. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-23 Completed Date: 2010-10-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8611087 Medline TA: Immunol Res Country: United States |
Other Details:
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Languages: eng Pagination: 78-85 Citation Subset: IM |
Affiliation:
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Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Ross 965, Baltimore, MD 21205, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Allergy and Immunology Animals Baltimore Biomedical Research* Humans Kidney / immunology, injuries* Mice Mice, Inbred C57BL Reperfusion Injury / immunology* T-Lymphocytes, Regulatory / immunology*, metabolism Universities |
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