| Immunologic regulation in pregnancy. | |
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MedLine Citation:
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PMID: 92318 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Theories to explain the failure of rejection of the fetus by the mother during pregnancy include immunologic privilege of the uterus as a graft site, lack of transplantation antigen expression on the trophoblast, weakening of maternal cellular immunity during pregnancy, and separation of maternal and fetal circulations. Evidence for and against each of these theories is discussed. Local concentration of a variety of hormones, including human chorionic gonadotropin (HCG), sex steroids, alpha-fetoprotein, and immunoglobulins, could provide a blocking mechanism to prevent maternal cellular immune attack. Possibly, progesterone, antibodies, and immune complexes are important in protecting the placenta and ultimately the fetus from rejection. Elucidation of regulatory mechanisms in pregnancy may be applicable to other problems in immunology. |
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Authors:
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D P Stites; C S Pavia; L E Clemens; R W Kuhn; P K Siiteri |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Arthritis and rheumatism Volume: 22 ISSN: 0004-3591 ISO Abbreviation: Arthritis Rheum. Publication Date: 1979 Nov |
Date Detail:
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Created Date: 1980-01-28 Completed Date: 1980-01-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370605 Medline TA: Arthritis Rheum Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1300-7 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies
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analysis Antigen-Antibody Complex Chorionic Gonadotropin / physiology Female Fetus / immunology* HLA Antigens / analysis Humans Immunity* Immunity, Cellular Male Maternal-Fetal Exchange Pregnancy* Progesterone / physiology Trophoblasts / immunology Uterus / immunology alpha-Fetoproteins / physiology |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; 0/Antigen-Antibody Complex; 0/Chorionic Gonadotropin; 0/HLA Antigens; 0/alpha-Fetoproteins; 57-83-0/Progesterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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