Document Detail

Immunologic regulation in pregnancy.
MedLine Citation:
PMID:  92318     Owner:  NLM     Status:  MEDLINE    
Theories to explain the failure of rejection of the fetus by the mother during pregnancy include immunologic privilege of the uterus as a graft site, lack of transplantation antigen expression on the trophoblast, weakening of maternal cellular immunity during pregnancy, and separation of maternal and fetal circulations. Evidence for and against each of these theories is discussed. Local concentration of a variety of hormones, including human chorionic gonadotropin (HCG), sex steroids, alpha-fetoprotein, and immunoglobulins, could provide a blocking mechanism to prevent maternal cellular immune attack. Possibly, progesterone, antibodies, and immune complexes are important in protecting the placenta and ultimately the fetus from rejection. Elucidation of regulatory mechanisms in pregnancy may be applicable to other problems in immunology.
D P Stites; C S Pavia; L E Clemens; R W Kuhn; P K Siiteri
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Arthritis and rheumatism     Volume:  22     ISSN:  0004-3591     ISO Abbreviation:  Arthritis Rheum.     Publication Date:  1979 Nov 
Date Detail:
Created Date:  1980-01-28     Completed Date:  1980-01-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370605     Medline TA:  Arthritis Rheum     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1300-7     Citation Subset:  AIM; IM    
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MeSH Terms
Antibodies / analysis
Antigen-Antibody Complex
Chorionic Gonadotropin / physiology
Fetus / immunology*
HLA Antigens / analysis
Immunity, Cellular
Maternal-Fetal Exchange
Progesterone / physiology
Trophoblasts / immunology
Uterus / immunology
alpha-Fetoproteins / physiology
Reg. No./Substance:
0/Antibodies; 0/Antigen-Antibody Complex; 0/Chorionic Gonadotropin; 0/HLA Antigens; 0/alpha-Fetoproteins; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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