Document Detail

Immunologic reconstitution in the DiGeorge syndrome by fetal thymic transplant.
MedLine Citation:
PMID:  1148386     Owner:  NLM     Status:  MEDLINE    
An infant with idiopathic hypoparathyroidism was found to have no evidence of thymus by radiologic examinations, including pneumomediastinum. Immunoglobulin concentrations were normal but there was clear evidence of inadequate cellular immunity including gradually developing lymphopenia. The infant suffered recurrent diarrhea and pneumonia, chronic rhinorrhea and moniliasis. At age 7 months fetal thymic tissue was implanted in the rectus abdominis muscle. There was immediate increase in lymphocyte counts which have remained normal on most determinations. Other aspects of immunologic function were restored and remain intact. The child, now 6 years of age, although mentally retarded, has no unusual infections. Immunologic reconstitution was thus achieved by transplant of fetal thymus.
W W Cleveland
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Birth defects original article series     Volume:  11     ISSN:  0547-6844     ISO Abbreviation:  Birth Defects Orig. Artic. Ser.     Publication Date:  1975  
Date Detail:
Created Date:  1975-11-01     Completed Date:  1975-11-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0003403     Medline TA:  Birth Defects Orig Artic Ser     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  352-6     Citation Subset:  IM    
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MeSH Terms
Antibody Formation
Calcium / metabolism
Diphtheria Toxoid
Hypoparathyroidism / therapy*
Lymphocyte Activation
Mental Retardation / etiology
Parathyroid Glands / abnormalities*,  transplantation
Phosphorus / metabolism
Pneumomediastinum, Diagnostic
Thymus Gland / abnormalities*,  transplantation
Transplantation, Homologous
Reg. No./Substance:
0/Diphtheria Toxoid; 7440-70-2/Calcium; 7723-14-0/Phosphorus

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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