Document Detail


Immunologic properties and clinical features of local allergic rhinitis.
MedLine Citation:
PMID:  22498269     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: There is still no study involving the immunologic properties of local allergic rhinitis (LAR). We aimed to determine the immunologic profile of patients with LAR by analyzing cytokines in the serum and nasal secretions and correlated the results with clinical characteristics.
METHODS: Ten healthy volunteers (group A), nine patients with allergic rhinitis (group B), and seven patients with LAR (group C) were enrolled.
MAIN OUTCOME MEASURES: Changes in nasal symptoms, total nasal volume (TNV), and minimal cross-sectional area (MCA) were compared. We performed a Quantibody array for interleukin (IL)-4, IL-13, IL-3, IL-5, granulocyte-macrophage colony-stimulating factor, stem cell factor, IL-10, and transforming growth factor β (TGF-β) using serum and nasal secretions.
RESULTS: Patients in group C had more aggravated rhinorrhea and itching than patients in group B (p < .05). The change in TNV and MCA was greater in groups B and C than in group A (p < .01). The serum concentration of IL-10 in group C was higher than in group A or B (p < .001). The concentration of IL-13, IL-5, IL-10, and TGF-β in group C was higher than in group A or B in the nasal secretions (p < .001).
CONCLUSIONS: Patients with LAR have similar symptoms, similar changes in TNV and MCA, and a similar profile of cytokine production and nasal secretions than those with allergic rhinitis. More prominent immunomodulating properties of LAR patients could in part explain the absence of systemic allergic responses.
Authors:
Young Hyo Kim; Chang-Shin Park; Tae Young Jang
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale     Volume:  41     ISSN:  1916-0216     ISO Abbreviation:  J Otolaryngol Head Neck Surg     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-04-13     Completed Date:  2012-08-21     Revised Date:  2013-04-10    
Medline Journal Info:
Nlm Unique ID:  101479544     Medline TA:  J Otolaryngol Head Neck Surg     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  51-7     Citation Subset:  IM    
Affiliation:
Department of Otorhinolaryngology-Head and Neck Surgery, Inha University College of Medicine, Incheon, Korea.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Cytokines / immunology,  metabolism*
Female
Follow-Up Studies
Granulocyte-Macrophage Colony-Stimulating Factor / immunology,  metabolism*
Humans
Immunity, Innate / immunology*
Immunologic Factors / immunology*
Male
Middle Aged
Nasal Mucosa / immunology*,  metabolism,  pathology
Retrospective Studies
Rhinitis, Allergic, Perennial / diagnosis,  immunology*
Young Adult
Chemical
Reg. No./Substance:
0/Cytokines; 0/Immunologic Factors; 83869-56-1/Granulocyte-Macrophage Colony-Stimulating Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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