Document Detail


Immunologic profile of patients with cured Hodgkin's disease.
MedLine Citation:
PMID:  141726     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Blood lymphocytes from 9 patients with Hodgkin's disease (HD) were studied. The results were compared with those of 6 seminoma testis patients and 9 healthy unrelated controls. All patients were in complete and unmaintained remission more than 10 years after termination of radiotherapy. The mean T-lymphocyte count of HD patients was lower than that of controls and seminoma testis patients. Lymphocyte DNA synthesis induced by pokeweed mitogen and phytohaemagglutinin was normal in both patient groups. Concanavalin A-induced DNA synthesis was low in 4 patients with HD although the mean stimulation of the group did not differ from controls or seminoma testis patients. Lymphocyte activation by PPD was slightly decreased in the 2 patient groups. No increase in spontaneous lymphocyte DNA synthesis was observed. The responding and stimulatory capacity in mixed lymphocyte culture was decreased in 3 and 2 HD patients respectively. 4 out of the 9 patients with HD but none with seminoma testis displayed severe impairment in T-lymphocyte functions. As 1 of the 4 had been treated solely by surgery, late effects of irradiation can only partly explain the results. The results may favour a hypothesis postulating a constitutional defect contributing to the immunoincompetence in HD.
Authors:
M Bjorkholm; G Holm; H Mellstedt
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Scandinavian journal of haematology     Volume:  18     ISSN:  0036-553X     ISO Abbreviation:  Scand J Haematol     Publication Date:  1977 May 
Date Detail:
Created Date:  1977-08-12     Completed Date:  1977-08-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404507     Medline TA:  Scand J Haematol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  361-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Child
Concanavalin A / pharmacology
DNA / biosynthesis
Dysgerminoma / blood,  immunology
Female
Hodgkin Disease / blood,  immunology*
Humans
Lectins / pharmacology
Leukocyte Count
Lymphocyte Activation / drug effects
Lymphocyte Culture Test, Mixed
Lymphocytes / metabolism
Male
Middle Aged
Mitogens / pharmacology
Prognosis
Remission, Spontaneous
Testicular Neoplasms / blood,  immunology
Chemical
Reg. No./Substance:
0/Lectins; 0/Mitogens; 11028-71-0/Concanavalin A; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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