Document Detail

Immunologic profile of patients with cured Hodgkin's disease.
MedLine Citation:
PMID:  141726     Owner:  NLM     Status:  MEDLINE    
Blood lymphocytes from 9 patients with Hodgkin's disease (HD) were studied. The results were compared with those of 6 seminoma testis patients and 9 healthy unrelated controls. All patients were in complete and unmaintained remission more than 10 years after termination of radiotherapy. The mean T-lymphocyte count of HD patients was lower than that of controls and seminoma testis patients. Lymphocyte DNA synthesis induced by pokeweed mitogen and phytohaemagglutinin was normal in both patient groups. Concanavalin A-induced DNA synthesis was low in 4 patients with HD although the mean stimulation of the group did not differ from controls or seminoma testis patients. Lymphocyte activation by PPD was slightly decreased in the 2 patient groups. No increase in spontaneous lymphocyte DNA synthesis was observed. The responding and stimulatory capacity in mixed lymphocyte culture was decreased in 3 and 2 HD patients respectively. 4 out of the 9 patients with HD but none with seminoma testis displayed severe impairment in T-lymphocyte functions. As 1 of the 4 had been treated solely by surgery, late effects of irradiation can only partly explain the results. The results may favour a hypothesis postulating a constitutional defect contributing to the immunoincompetence in HD.
M Bjorkholm; G Holm; H Mellstedt
Related Documents :
8175036 - Serum and urinary monoclonal immunoglobulins in hodgkin's disease. report of two cases.
17651116 - The influence of hemodialysis on p-wave signal-averaged electrocardiogram findings.
8396696 - The significance of serum levels of soluble 60kda receptors for tumor necrosis factor i...
1893346 - Stage i and ii subdiaphragmatic hodgkin's disease.
9114096 - Pancreatitis: evaluation with mr cholangiopancreatography in children.
157096 - The chronicity of symptoms and disability in reiter's syndrome. an analysis of 131 cons...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Scandinavian journal of haematology     Volume:  18     ISSN:  0036-553X     ISO Abbreviation:  Scand J Haematol     Publication Date:  1977 May 
Date Detail:
Created Date:  1977-08-12     Completed Date:  1977-08-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404507     Medline TA:  Scand J Haematol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  361-8     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Concanavalin A / pharmacology
DNA / biosynthesis
Dysgerminoma / blood,  immunology
Hodgkin Disease / blood,  immunology*
Lectins / pharmacology
Leukocyte Count
Lymphocyte Activation / drug effects
Lymphocyte Culture Test, Mixed
Lymphocytes / metabolism
Middle Aged
Mitogens / pharmacology
Remission, Spontaneous
Testicular Neoplasms / blood,  immunology
Reg. No./Substance:
0/Lectins; 0/Mitogens; 11028-71-0/Concanavalin A; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Quantitative histological changes in isoproterenol induced cardiac growth.
Next Document:  Increased ATP-ase activity of lymphocytes after rosette formation with sheep red blood cells.