| Immunologic observations in canine interstitial nephritis. | |
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MedLine Citation:
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PMID: 4106382 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Immunofluorescence studies in cases of chronic interstitial nephritis (CIN) in the dog demonstrated deposition of canine IgC and C'3 in the thickened capillary walls of the glomeruli and in the mesangium. Eluates obtained from the nephritic kidneys contained antibodies of IgG type and reacted with autologous or homologous nephritic kidneys but not with normal kidneys or with any normal canine tissue. The staining pattern of fluorescein-conjugated eluates was similar to that obtained with anti-canine IgG or anti-canine C'3. The eluates did not contain leptospiral antibodies. The findings indicate that complement-fixing immune complexes are deposited in the damaged glomeruli in CIN. The nature of the antigen involved in these complexes is unknown, but it does not seem to be a component of normal canine tissue and could thus be viral or bacterial. |
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Authors:
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K Krohn; M Mero; A Oksanen; M Sandholm |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of pathology Volume: 65 ISSN: 0002-9440 ISO Abbreviation: Am. J. Pathol. Publication Date: 1971 Oct |
Date Detail:
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Created Date: 1971-12-07 Completed Date: 1971-12-07 Revised Date: 2010-06-22 |
Medline Journal Info:
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Nlm Unique ID: 0370502 Medline TA: Am J Pathol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 157-72 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Urea Nitrogen Complement Fixation Tests Complement System Proteins Dog Diseases / immunology* Dogs Female Fluorescent Antibody Technique Immune Sera Immunoglobulin G Kidney / analysis Kidney Glomerulus / immunology, pathology Male Microscopy, Fluorescence Nephritis, Interstitial / immunology, pathology, veterinary* Proteinuria Staining and Labeling |
| Chemical | |
Reg. No./Substance:
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0/Immune Sera; 0/Immunoglobulin G; 9007-36-7/Complement System Proteins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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