| Immunologic and neuroendocrine interactions in pregnancy. | |
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MedLine Citation:
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PMID: 2680937 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The neuroendocrine system helps in the success of the fetal graft by suppressing maternal cellular immune response against the foreign paternal histocompatibility (HLA) antigens. In addition, placenta absorbs the antibodies directed against the paternal HLA antigens, thus inhibiting the humoral rejection of the fetal graft. In contrast, neuropeptides released in the maternal blood stream under adverse mental states may stimulate lymphocyte blastogenesis and natural killer (NK) cell activity resulting in premature loss of the fetus. Further, homozygosity of a lethal gene which is in linkage disequilibrium with HLA genes may have a role in some unexplained fetal deaths. |
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Authors:
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R Rani; K K Mittal |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Indian journal of pediatrics Volume: 56 ISSN: 0019-5456 ISO Abbreviation: Indian J Pediatr Publication Date: 1989 Mar-Apr |
Date Detail:
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Created Date: 1989-12-21 Completed Date: 1989-12-21 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 0417442 Medline TA: Indian J Pediatr Country: INDIA |
Other Details:
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Languages: eng Pagination: 181-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Female Genes, Lethal Gonadal Steroid Hormones / immunology Humans Immune Tolerance / immunology* Neurosecretory Systems / immunology* Placenta / immunology* Placental Hormones / immunology Pregnancy / immunology* Pregnancy Complications / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Gonadal Steroid Hormones; 0/Placental Hormones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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