| Immunologic and inflammatory responses during pregnancy. | |
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MedLine Citation:
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PMID: 6541701 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rheumatoid arthritis commonly improves markedly during pregnancy, and it has been suggested that this reflects a decrease in immunological or inflammatory effector mechanisms. We elicited a delayed type hypersensitivity (DTH) response to Burro RBC, by injection of primed lymphocytes and antigen into murine footpads. The swelling induced in footpads of pregnant mice was not significantly different from that seen in controls, nor was the response to a non-immunologic inflammatory stimulus, carrageenan, decreased in pregnant mice. On the other hand, a defect in the priming or induction phase of a primary DTH response was impaired in pregnancy, but whether this is relevant to the pregnancy induced remission of rheumatoid arthritis remains to be demonstrated. |
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Authors:
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D Holland; P Bretscher; A S Russell |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of clinical & laboratory immunology Volume: 14 ISSN: 0141-2760 ISO Abbreviation: J Clin Lab Immunol Publication Date: 1984 Aug |
Date Detail:
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Created Date: 1984-12-18 Completed Date: 1984-12-18 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7808987 Medline TA: J Clin Lab Immunol Country: ITALY |
Other Details:
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Languages: eng Pagination: 177-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens Carrageenan / administration & dosage Edema / etiology Female Humans Hypersensitivity, Delayed / immunology Inflammation / chemically induced Leukocytes / immunology* Mice Mice, Inbred Strains Pregnancy Pregnancy Complications / immunology, physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/Antigens; 9000-07-1/Carrageenan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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