Document Detail

Immunologic factors in patients with chronic polypoid sinusitis.
MedLine Citation:
PMID:  20845638     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Nasal polyposis is the benign protrusion of soft tissue into the nasal cavity, with multifactorial origin. This study is designed to examine the suggested role of IgE and CD4 and CD8 lymphocytes in the pathogenesis of nasalpolyposis. METHODOLOGY: Blood samples were taken from 32 patients with chronic polypoid sinusitis and 32 controls. CD4 and CD8 total lymphocyte count were determined by flow cytometry and the level of serum IgE was measured by ELISA. Nasal discharge samples were also collected for determining IgE level in both patients and controls during surgery. RESULTS: In 68.8% of patients a history of allergy was present. The level of nasal discharge IgE was significantly higher (p < 0.001) in patients compared to controls, but the difference between serum IgE levels was not significant (p > 0.05). CD8 concentration and blood lymphocytes were significantly higher (p < 0.001) in the patients group, while CD4 concentration was significantly lower (p < .OO01) in them. Finally, CD4/CD8 ratio was significantly lower(p < 0. 001) in the patients group. CONCLUSION: This study suggests that a change in the amount of CD4 and CD8 lymphocytes and an increased level of local IgE contribute to nasal polyposis, but the results should be confirmed in more extensive studies including cytokine analyses. Such increasing insights in the pathophysiology of nasal polyposis open perspectives for new pharmacological treatment options, with immunologic factors as potential targets.
S Nikakhlagh; M Ghafourian-Boroujerdnia; N Saki; M R Soltan-Moradi; F Rahim
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nigerian journal of medicine : journal of the National Association of Resident Doctors of Nigeria     Volume:  19     ISSN:  1115-2613     ISO Abbreviation:  Niger J Med     Publication Date:    2010 Jul-Sep
Date Detail:
Created Date:  2010-09-17     Completed Date:  2010-09-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888321     Medline TA:  Niger J Med     Country:  Nigeria    
Other Details:
Languages:  eng     Pagination:  316-9     Citation Subset:  IM    
Department of Otolaryngology, Head and Neck Surgery, Ahwaz Jondishapour University of Medical Sciences, Ahwaz, Iran.
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MeSH Terms
CD4 Lymphocyte Count
CD8-Positive T-Lymphocytes / immunology
Case-Control Studies
Enzyme-Linked Immunosorbent Assay
Flow Cytometry
Immunoglobulin E / blood,  immunology*
Middle Aged
Nasal Polyps / immunology*
Sinusitis / immunology*
Reg. No./Substance:
37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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