Document Detail

Immunologic factors in human milk: the effects of gestational age and pasteurization.
MedLine Citation:
PMID:  16280560     Owner:  NLM     Status:  MEDLINE    
This study compared concentrations of total protein, lysozyme, and immunoglobulins (IgA, IgG, IgM) in samples of colostrum (n=101) obtained from mothers of infants<32 weeks, 32 to 36(6) 7 weeks, and >or=37 weeks gestational age, both before and after pasteurization. Total protein was measured by refraction index, lysozyme by the lysoplate method, and immunoglobulins through the radial immunodiffusion technique. The total protein concentration was greater in colostrum of the <32 weeks and 32 to 36(6) 7 weeks categories compared to full-term (P<.001), while concentrations of lysozyme and IgM were similar. IgA concentrations were higher in the <32 weeks group compared to the full-term and similar to the 32 to 36(6) 7 weeks group (P<.05). The IgG was higher in the <32 weeks category compared to 32 to 36(6) 7 weeks, and both were similar to the full-term (P<.05). Pasteurization significantly decreased all of the factors analyzed.
Alvaro Koenig; Edna Maria de Albuquerque Diniz; Sonia França Correia Barbosa; Flávio Adolfo Costa Vaz
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of human lactation : official journal of International Lactation Consultant Association     Volume:  21     ISSN:  0890-3344     ISO Abbreviation:  J Hum Lact     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-11-10     Completed Date:  2006-01-31     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8709498     Medline TA:  J Hum Lact     Country:  United States    
Other Details:
Languages:  eng     Pagination:  439-43     Citation Subset:  N    
Pediatrics Department, School of Medicine, University of São Paulo, Brazil.
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MeSH Terms
Analysis of Variance
Colostrum / immunology*
Food Handling / methods*
Gestational Age
Hot Temperature* / adverse effects
Immunoglobulin A / analysis
Immunoglobulin G / analysis
Immunoglobulin M / analysis
Milk, Human / immunology*
Muramidase / analysis
Reg. No./Substance:
0/Immunoglobulin A; 0/Immunoglobulin G; 0/Immunoglobulin M; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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