Document Detail

Immunologic evaluation of patients with recurrent ear, nose, and throat infections.
MedLine Citation:
PMID:  19144299     Owner:  NLM     Status:  MEDLINE    
PURPOSE: In this study, we aimed to study the frequency of possible underlying immunodeficiency responsible for susceptibility to ear, nose, and throat (ENT) infection. MATERIALS AND METHODS: One hundred three (72 males and 31 females) consecutive children and adult patients with history of recurrent or chronic ENT infections, referred by otolaryngologists to the Department of Allergy and Clinical Immunology, Children's Medical Center, Tehran University of Medical Sciences (Tehran, Iran), were enrolled to the study from March 2003 to March 2006. For each patient, demographic information and medical histories of any ENT infections were collected by reviewing the patient's records. We measured immunoglobulin isotype concentrations and immunoglobulin (Ig) G subclasses by nephelometry and enzyme-linked immunosorbent assay methods, respectively. Of 103 patients, 75 received unconjugated pneumococcus polyvalent vaccine, and blood samples were taken before and 21 days after vaccination. Specific antibodies against whole pneumococcal antigens were measured using enzyme-linked immunosorbent assay method. Existence of bronchiectasis was confirmed in each patient using high resolution computed tomography scan. RESULTS: Among 103 patients, 17 (16.5%) patients were diagnosed to have defects in antibody-mediated immunity including 6 patients with immunoglobulin class deficiency (2 common variable deficiency and 4 IgA deficiency), 3 with IgG subclass deficiency (2 IgG2 and 1 IgG3), and 8 with specific antibody deficiency against polysaccharide antigens. In our series, bronchiectasis was detected in 5 cases associated with primary immunodeficiency. CONCLUSIONS: Long-standing history of ENT infections could be an alarm for ENT infections associated with primary antibody deficiency.
Asghar Aghamohammadi; Mostafa Moin; Alireza Karimi; Mohsen Naraghi; Fariborz Zandieh; Anna Isaeian; Amir Tahaei; Mojtaba Talaei-Khoei; Ali Kouhi; Sina Abdollahzade; Nima Pouladi; Golnaz Heidari; Ali Akbar Amirzargar; Nima Rezaei; Amir Arvin Sazgar
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-06-16
Journal Detail:
Title:  American journal of otolaryngology     Volume:  29     ISSN:  1532-818X     ISO Abbreviation:  Am J Otolaryngol     Publication Date:    2008 Nov-Dec
Date Detail:
Created Date:  2009-01-15     Completed Date:  2009-04-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8000029     Medline TA:  Am J Otolaryngol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  385-92     Citation Subset:  IM    
Department of Pediatrics, Children's Medical Center Hospital, Immunology, Asthma and Allergy Research Institute, Medical Sciences/University of Tehran, Tehran, Iran.
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MeSH Terms
Case-Control Studies
Child, Preschool
Follow-Up Studies
IgA Deficiency / diagnosis,  epidemiology
IgG Deficiency / diagnosis,  epidemiology
Immunologic Deficiency Syndromes / diagnosis*,  epidemiology
Iran / epidemiology
Middle Aged
Monitoring, Immunologic
Otitis Media / epidemiology,  immunology*
Pharyngitis / epidemiology,  immunology*
Rhinitis / epidemiology,  immunology*
Risk Assessment
Severity of Illness Index
Young Adult

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