|Immunologic evaluation of patients with recurrent ear, nose, and throat infections.|
|PMID: 19144299 Owner: NLM Status: MEDLINE|
|PURPOSE: In this study, we aimed to study the frequency of possible underlying immunodeficiency responsible for susceptibility to ear, nose, and throat (ENT) infection. MATERIALS AND METHODS: One hundred three (72 males and 31 females) consecutive children and adult patients with history of recurrent or chronic ENT infections, referred by otolaryngologists to the Department of Allergy and Clinical Immunology, Children's Medical Center, Tehran University of Medical Sciences (Tehran, Iran), were enrolled to the study from March 2003 to March 2006. For each patient, demographic information and medical histories of any ENT infections were collected by reviewing the patient's records. We measured immunoglobulin isotype concentrations and immunoglobulin (Ig) G subclasses by nephelometry and enzyme-linked immunosorbent assay methods, respectively. Of 103 patients, 75 received unconjugated pneumococcus polyvalent vaccine, and blood samples were taken before and 21 days after vaccination. Specific antibodies against whole pneumococcal antigens were measured using enzyme-linked immunosorbent assay method. Existence of bronchiectasis was confirmed in each patient using high resolution computed tomography scan. RESULTS: Among 103 patients, 17 (16.5%) patients were diagnosed to have defects in antibody-mediated immunity including 6 patients with immunoglobulin class deficiency (2 common variable deficiency and 4 IgA deficiency), 3 with IgG subclass deficiency (2 IgG2 and 1 IgG3), and 8 with specific antibody deficiency against polysaccharide antigens. In our series, bronchiectasis was detected in 5 cases associated with primary immunodeficiency. CONCLUSIONS: Long-standing history of ENT infections could be an alarm for ENT infections associated with primary antibody deficiency.|
|Asghar Aghamohammadi; Mostafa Moin; Alireza Karimi; Mohsen Naraghi; Fariborz Zandieh; Anna Isaeian; Amir Tahaei; Mojtaba Talaei-Khoei; Ali Kouhi; Sina Abdollahzade; Nima Pouladi; Golnaz Heidari; Ali Akbar Amirzargar; Nima Rezaei; Amir Arvin Sazgar|
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|Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-06-16|
|Title: American journal of otolaryngology Volume: 29 ISSN: 1532-818X ISO Abbreviation: Am J Otolaryngol Publication Date: 2008 Nov-Dec|
|Created Date: 2009-01-15 Completed Date: 2009-04-09 Revised Date: -|
Medline Journal Info:
|Nlm Unique ID: 8000029 Medline TA: Am J Otolaryngol Country: United States|
|Languages: eng Pagination: 385-92 Citation Subset: IM|
|Department of Pediatrics, Children's Medical Center Hospital, Immunology, Asthma and Allergy Research Institute, Medical Sciences/University of Tehran, Tehran, Iran. email@example.com|
|APA/MLA Format Download EndNote Download BibTex|
IgA Deficiency / diagnosis, epidemiology
IgG Deficiency / diagnosis, epidemiology
Immunologic Deficiency Syndromes / diagnosis*, epidemiology
Iran / epidemiology
Otitis Media / epidemiology, immunology*
Pharyngitis / epidemiology, immunology*
Rhinitis / epidemiology, immunology*
Severity of Illness Index
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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