Document Detail

Immunologic evaluation of 24 month course of sublingual immunotherapy.
MedLine Citation:
PMID:  7840022     Owner:  NLM     Status:  MEDLINE    
58 patients under 12 years of age, positive to mites (Dermatophagoides pteronyssinus and D. farinae) according to prick, in vitro specific IgE and challenge tests, suffering from asthma and rhinitis, have been randomly assigned on a double blind basis to receive per os either a biologically standardized extract of mites (active therapy TA = 30 patients) or a saline buffered solution (placebo TP = 28 patients). The serologic results are interesting. The specific IgE level differences of significance are, in comparison with the placebo group. In particular, we did observe the increase of the specific IgE level in the placebo group during the autumn, whereas after 12 months and after 24 months of active treatment there was a clear (p < 0.01) decline in serum specific IgE antibody. In the active group, there was a significant increase in IgG antibodies level after 12 and 24 months and a significant increase in IgG4 level after 24 months. In the placebo group, the level of IgG antibodies was unchanged. In the actively treated patients, a significant increase of CD8+ values and a significant reduction of the ratio CD4+/CD8+ was observed.
M G Tari; M Mancino; F Madonna; L Buzzoni; S Parmiani
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Allergologia et immunopathologia     Volume:  22     ISSN:  0301-0546     ISO Abbreviation:  Allergol Immunopathol (Madr)     Publication Date:    1994 Sep-Oct
Date Detail:
Created Date:  1995-03-02     Completed Date:  1995-03-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370073     Medline TA:  Allergol Immunopathol (Madr)     Country:  SPAIN    
Other Details:
Languages:  eng     Pagination:  209-16     Citation Subset:  IM; X    
Servizio Autonomo di Allergologia E Fisiopatologia Respiratoria, Arienzo, Caserta, Italy.
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MeSH Terms
Administration, Sublingual
Antibody Specificity
Antigens, Dermatophagoides
Asthma / etiology,  immunology,  therapy*
CD4-CD8 Ratio
Child, Preschool
Desensitization, Immunologic*
Double-Blind Method
Glycoproteins / administration & dosage*,  immunology
Immunoglobulin E / blood,  immunology
Immunoglobulin G / blood,  immunology
Lymphocyte Count
Lymphocyte Subsets
Mites / immunology*
Rhinitis, Allergic, Perennial / etiology,  immunology,  therapy*
Treatment Outcome
Reg. No./Substance:
0/Antigens, Dermatophagoides; 0/Glycoproteins; 0/Immunoglobulin G; 37341-29-0/Immunoglobulin E

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