Document Detail


Immunologic effects of long-term thymopentin treatment in patients with HIV-induced lymphadenopathy syndrome.
MedLine Citation:
PMID:  2644387     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The immunologic effects of a year-long therapeutic trial with the synthetic thymic hormone thymopentin were investigated in 29 patients with human immunodeficiency virus--induced lymphadenopathy syndrome. Peripheral T4 and T8 lymphocyte subsets and in vitro immunoglobulin synthesis with pokeweed mitogen (PWM) were monitored before treatment, every 4 months during treatment, and after treatment. Significant increases in circulating T4 cells and a reduction of PWM-induced immunoglobulin suppression were noted in the 21 patients who completed the trial. Furthermore, addition of thymopentin to the in vitro cultures improved the PWM response of T and B cells. After thymopentin treatment, a slight variability of clinical symptoms, including weight loss, diarrhea, night sweats, or a combination of these, was also noted in several subjects.
Authors:
F Silvestris; A Gernone; M A Frassanito; F Dammacco
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of laboratory and clinical medicine     Volume:  113     ISSN:  0022-2143     ISO Abbreviation:  J. Lab. Clin. Med.     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1989-03-21     Completed Date:  1989-03-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375375     Medline TA:  J Lab Clin Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  139-44     Citation Subset:  AIM; IM; X    
Affiliation:
Istituto di Patologia Medica, University of Bari School of Medicine, Italy.
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MeSH Terms
Descriptor/Qualifier:
AIDS-Related Complex / drug therapy*,  immunology
Adjuvants, Immunologic / therapeutic use*
Female
Humans
Immunoglobulin G / biosynthesis
Lymphocyte Activation
Lymphocytes / immunology
Male
Peptide Fragments / therapeutic use*
Thymopentin
Thymopoietins / therapeutic use*
Thymus Hormones / therapeutic use*
Chemical
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Immunoglobulin G; 0/Peptide Fragments; 0/Thymopoietins; 0/Thymus Hormones; 69558-55-0/Thymopentin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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