Document Detail

Immunologic dysfunction among PBB-exposed Michigan dairy farmers.
MedLine Citation:
PMID:  222196     Owner:  NLM     Status:  MEDLINE    
In 1973 inadvertent contamination occurred in a special farm feed supplement for lactating cows. Polybrominated biphenyls (PBBs) were used in place of magnesium oxide resulting in serious harm to farm animals, including cattle, chickens, geese, ducks. Farm families, accustomed to eating their own products, were most heavily exposed. To further study the impact of PBBs, 45 adult Michigan farm residents who were originally examined in a clinical field survey were further studied with respect to their immunologic status. For comparison, 46 dairy farm residents in Wisconsin, who had not eaten PBB-contaminated food, were examined, as were 79 healthy subjects in New York City. Abnormalities in the Michigan group included significant decrease in absolute numbers and percentages of T and B-lymphocytes and increased number of lymphocytes with no detectable surface markers ("null cells"). Significant reduction of in vitro immune function was noted in 35--40% of the Michigan farm residents who had eaten food containing PBB. Despite the absence of any apparent numerical reduction, both T and B lymphocyte subpopulations of peripheral blood lymphocytes showed evidence of functional defect. Ten of the 45 Michigan farmers studied showed impaired PHA-induced blastogeneic response, due to the decreased number and percent of T-cells in the PBLs. The decreased immune function detected among the PBB-exposed farm residents tended to affect families as a unit and was independent of exposed individuals' age or sex, speaking against the possibility of genetic predisposition.
J G Bekesi; H A Anderson; J P Roboz; J Roboz; A Fischbein; I J Selikoff; J F Holland
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  320     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  1979 May 
Date Detail:
Created Date:  1979-09-01     Completed Date:  1979-09-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  717-28     Citation Subset:  IM    
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MeSH Terms
Animal Feed
Biphenyl Compounds / poisoning*
Dairy Products
Food Contamination
Immunity / drug effects*
Lymphocytes / drug effects,  immunology
Middle Aged
Mitogens / pharmacology
New York
Occupational Diseases / chemically induced*,  immunology
Polybrominated Biphenyls / pharmacology,  poisoning*
Reg. No./Substance:
0/Biphenyl Compounds; 0/Mitogens; 0/Polybrominated Biphenyls

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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