Document Detail

Immunologic defects in lung cancer patients.
MedLine Citation:
PMID:  1107678     Owner:  NLM     Status:  MEDLINE    
Ninety-three patients with lung cancer were evaluated by delayed cutaneous hypersensitivity testing. Twenty-eight of these patients were evaluated by in vitro lymphocyte function. Thirty-three patients were evaluated prior to surgery and defects in the immune response were closely associated with unresectable disease. In vitro and in vivo studies indicate an antigen recognition defect in the cellular immune mechanisms of these patients. Preliminary studies suggest that the immunopotentiating agent Levamisole may be able to augment this defective cellular immunity in patients with lung cancer.
E C Holmes; S H Golub
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Publication Detail:
Type:  Clinical Trial; Comparative Study; In Vitro; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of thoracic and cardiovascular surgery     Volume:  71     ISSN:  0022-5223     ISO Abbreviation:  J. Thorac. Cardiovasc. Surg.     Publication Date:  1976 Feb 
Date Detail:
Created Date:  1976-03-24     Completed Date:  1976-03-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376343     Medline TA:  J Thorac Cardiovasc Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  161-8     Citation Subset:  AIM; IM    
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MeSH Terms
Adenocarcinoma / immunology*
Clinical Trials as Topic
Dinitrochlorobenzene / immunology
Hypersensitivity, Delayed / diagnosis
Immunity, Cellular* / drug effects
Immunologic Deficiency Syndromes / diagnosis*
Levamisole / therapeutic use
Lung Neoplasms / drug therapy,  immunology*
Lymphocyte Activation
Lymphocytes / physiopathology
Middle Aged
Skin Tests
Reg. No./Substance:
0/Placebos; 14769-73-4/Levamisole; 97-00-7/Dinitrochlorobenzene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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