Document Detail


Immunologic defects following trauma: a delay in immunoglobulin synthesis by cultured B cells following traumatic accidents but not elective surgery.
MedLine Citation:
PMID:  2342144     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The immune status of trauma patients was compared with that of elective surgery patients and normal controls. The trauma patients, the elective surgery patients, and the controls were all male, aged 18 to 36 years, in previous good health and with similar Injury Severity Scores. Only one of eight immunologic activities assayed distinguished between these groups of subjects. It was observed that the synthesis and secretion of immunoglobulins (Ig) in vitro by the circulating B cells of the trauma patients was markedly impaired when compared to Ig synthesis by B cells of the elective surgery patients or controls. Furthermore, it was demonstrated that the B cells, and not the T cells, Null cells, or monocytes, were defective in the trauma patients. The results indicate that diminished Ig synthesis and secretion by the circulating B cells of the trauma patients cannot be attributed to the surgery; rather, it appears that the defects in the B cells are a direct result of the trauma.
Authors:
M Richter; C A Jodouin; D Moher; P Barron
Related Documents :
3026184 - Labial fusion in prepubescent girls: a marker for sexual abuse?
9457044 - Interhospital versus direct scene transfer of major trauma patients in a rural trauma s...
12119084 - Rehabilitation outcome after primary subarachnoid haemorrhage.
10205814 - Treatment of decompression illness and latrogenic gas embolism.
22297874 - Transcranial sonography as a diagnostic tool for parkinson's disease: a pilot study in ...
888064 - Peritoneovenous shunting for ascites.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of trauma     Volume:  30     ISSN:  0022-5282     ISO Abbreviation:  J Trauma     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-06-25     Completed Date:  1990-06-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376373     Medline TA:  J Trauma     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  590-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Pathology, Faculty of Medicine, University of Ottawa.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
B-Lymphocytes / metabolism*
Cells, Cultured
Humans
Immunoglobulins / biosynthesis*
Injury Severity Score
Male
Surgical Procedures, Operative*
Wounds and Injuries / immunology*
Chemical
Reg. No./Substance:
0/Immunoglobulins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Glucose turnover, oxidation, and indices of recycling in severely traumatized patients.
Next Document:  Thoracic vascular injuries: a post mortem study.