| Immunologic aspects of multiple sclerosis. | |
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MedLine Citation:
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PMID: 21425265 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Multiple sclerosis is an inflammatory and degenerative disease of the central nervous system characterized by demyelination and axonal loss. Genetic and environmental factors contribute to the risk of immune dysregulation in multiple sclerosis. The review focuses on the immunopathogenic role played by various lymphocyte subsets and their cytokine products in the onset and disease progression, and the role of regulatory immune cells in disease remission. The mechanism of action of approved and experimental therapies, and how these mechanisms support the immunopathogenesis paradigm, is also reviewed. |
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Authors:
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Sridhar Boppana; Hui Huang; Kouichi Ito; Suhayl Dhib-Jalbut |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Mount Sinai journal of medicine, New York Volume: 78 ISSN: 1931-7581 ISO Abbreviation: Mt. Sinai J. Med. Publication Date: 2011 Mar-Apr |
Date Detail:
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Created Date: 2011-03-22 Completed Date: 2011-07-27 Revised Date: 2011-08-26 |
Medline Journal Info:
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Nlm Unique ID: 0241032 Medline TA: Mt Sinai J Med Country: United States |
Other Details:
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Languages: eng Pagination: 207-20 Citation Subset: IM |
Copyright Information:
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© 2011 Mount Sinai School of Medicine. |
Affiliation:
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Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, NJ, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Axons
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immunology,
pathology Disease Progression Environment Genetic Predisposition to Disease Humans Immunity* / drug effects, genetics Immunologic Factors* / immunology, therapeutic use Inflammation* / immunology, physiopathology Multiple Sclerosis* / drug therapy, genetics, immunology, pathology, physiopathology Myelin Sheath / immunology, pathology Nerve Degeneration / genetics, immunology, pathology, physiopathology Therapies, Investigational |
| Chemical | |
Reg. No./Substance:
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0/Immunologic Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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