Document Detail

Immunologic aspects of atopic dermatitis.
MedLine Citation:
PMID:  19818224     Owner:  NLM     Status:  MEDLINE    
Atopic dermatitis/eczema is a chronically relapsing, pruritic, and inflammatory skin disease. The term "atopic eczema/dermatitis syndrome" covers the "extrinsic" and "intrinsic" atopic dermatitis. The pathogenesis of atopic dermatitis includes complex interaction between the genetic background, skin barrier defects, abnormalities in innate and adaptive immunity, abnormalities of humoral and cellular immunity, and environmental influences. Understanding the immunopathogenesis of atopic dermatitis leads to new diagnostic and therapeutic approaches. The targets in atopic dermatitis are innate immunity including improvement of skin barrier defects by supplementing lipids or inhibiting proteases, and regulating antimicrobial peptides, adaptive immunity, and induction of regulatory T cells.
Jasna Lipozencić; Zrinjka Pastar; Sandra Marinović Kulisić; Ivan Pavić
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Acta dermatovenerologica Croatica : ADC     Volume:  17     ISSN:  1330-027X     ISO Abbreviation:  Acta Dermatovenerol Croat     Publication Date:  2009  
Date Detail:
Created Date:  2009-10-12     Completed Date:  2010-08-26     Revised Date:  2011-09-13    
Medline Journal Info:
Nlm Unique ID:  9433781     Medline TA:  Acta Dermatovenerol Croat     Country:  Croatia    
Other Details:
Languages:  eng     Pagination:  226-34     Citation Subset:  IM    
University Department of Dermatology and Venereology, Zagreb University Hospital Center and School of Medicine, Salata 4, HR-10000 Zagreb, Croatia.
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MeSH Terms
Cell Adhesion Molecules / immunology
Chemokines / immunology
Cytokines / immunology
Dendritic Cells / immunology
Dermatitis, Atopic / immunology*
Eczema / immunology*
Immunity, Innate
Lymphocyte Activation
T-Lymphocytes / immunology*
Reg. No./Substance:
0/Cell Adhesion Molecules; 0/Chemokines; 0/Cytokines

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