| Immunologic alterations in bleomycin-treated mice: role of pulmonary fibrosis in the modulation of immune responses. | |
| | |
MedLine Citation:
|
PMID: 8665057 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Among the side effects of bleomycin (BLM), a drug frequently used in the treatment of lymphomas and squamous-cell carcinomas, is pneumonitis with pulmonary fibrosis. The most prominent biochemical lesion associated with pulmonary fibrosis, a chronic debilitating and sometimes fatal disease, is an increase in the levels of collagen in the lung parenchyma. The mechanisms involved in the induction of this disease are still unclear, although results have suggested that the development of fibrosis may be immunologically mediated. There have, however, been no reports in the literature on the frequency and function of lymphocytes in the regional and systemic lymphoid tissues in BLM-induced pulmonary fibrosis. We therefore conducted a study, in which we inoculated C57Bl/6 mice intratracheally with BLM or saline, and tested the animals' lymphoid cells for various cell-mediated and humoral immune responses. The results indicated an increase in the number of lymphocytes in the lung-associated hilar lymph nodes, whereas the number of splenic lymphocytes was reduced as compared with control mice. Moreover, there was a significant inhibition of the antibody response to sheep erythrocytes in both the spleen and hilar lymph nodes of BLM-treated mice. Inhibition of the immune system appeared to be associated with the development of pulmonary fibrosis, and not to result from BLM toxicity, since the immune response of mice was not inhibited when they were injected with an identical dose of BLM under conditions that did not cause pulmonary fibrosis. Moreover, inhibition of splenic antibody responses was also observed in a hapten-induced model of pulmonary fibrosis, providing additional evidence that the induction of fibrosis and not the chemical toxicity of BLM was responsible for the modulation of immune responses. |
| | |
Authors:
|
J Zhu; A M Kaplan; S N Goud |
Related Documents
:
|
15330807 - Apoptosis and proliferation in lungs of human fetuses exposed to chorioamnionitis. 17218487 - Effects of the protein kinase inhibitor, imatinib mesylate, on epithelial/mesenchymal p... 15475557 - Signals and mechanisms of compensatory lung growth. 11134537 - Extended lung expression and increased tissue localization of viral il-10 with adenovir... 19048217 - Cytokine multiplex immunoassay: methodology and (clinical) applications. 22909087 - Curcuma dmso extracts and curcumin exhibit an anti-inflammatory and anti-catabolic effe... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: American journal of respiratory and critical care medicine Volume: 153 ISSN: 1073-449X ISO Abbreviation: Am. J. Respir. Crit. Care Med. Publication Date: 1996 Jun |
Date Detail:
|
Created Date: 1996-08-08 Completed Date: 1996-08-08 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 9421642 Medline TA: Am J Respir Crit Care Med Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1924-30 Citation Subset: AIM; IM |
Affiliation:
|
Department of Microbiology and Immunology, University of Kentucky, Lexington 40536-0084, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Bleomycin / adverse effects* Cell Division / drug effects Cells, Cultured / drug effects Female Hydroxyproline / drug effects, metabolism Interleukin-2 / metabolism Lymphocyte Subsets / drug effects Lymphocytes / cytology, drug effects Mice Mice, Inbred BALB C Mice, Inbred C57BL Phenotype Pulmonary Fibrosis / chemically induced, immunology*, metabolism Spleen / cytology, drug effects |
| Grant Support | |
ID/Acronym/Agency:
|
R01-ES06363/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Interleukin-2; 11056-06-7/Bleomycin; 51-35-4/Hydroxyproline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Serum indicators of free radical activity in idiopathic pulmonary fibrosis.
Next Document: High-affinity IgE receptor (FcepsilonRI)-bearing cells in bronchial biopsies from atopic and nonatop...