| Immunologic abnormalities in patients with malignant lymphoproliferative diseases. | |
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MedLine Citation:
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PMID: 323504 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The B- and T-lymphocyte distribution was studied in 45 patients with malignant lymphoproliferative diseases. Eight patients with untreated Hodgkin's disease had normal mean percentages of complement receptor lymphocyte (CRL) cells and T-cells; however, the mean absolute number of T-cells was decreased. T-lymphocytes were also decreased in 3 patients with Hodgkin's disease treated 7-24 months previously. The number of T-lymphocytes increased markedly in all patients after treatment. Lymphocyte surface markers in non-Hodgkin's lymphoma showed distinctive patterns. Patients with leukemic reticuloendotheliosis or "hairy cell leukemia" characteristically had low percentages of CRL but normal or increased percentages of surface immunoglobulin-positive lymphocytes. The mean percentage and number of T-lymphocytes in this group were normal. Eight patients with nodular lymphocytic lymphoma and 2 patients with nodular lymphocytic-histiocytic lymphoma had normal mean numbers of CRL but decreased numbers of T-lymphocytes. Of 6 patients with diffuse lymphocytic lymphoma, 4 had elevated percentages and numbers of CRL. Despite low percentages, normal numbers of T-lymphocytes were found in 3 of these patients. |
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Authors:
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C P Hunter; H Tannenbaum; W H Churchill; W C Moloney; P H Schur |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of the National Cancer Institute Volume: 58 ISSN: 0027-8874 ISO Abbreviation: J. Natl. Cancer Inst. Publication Date: 1977 May |
Date Detail:
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Created Date: 1977-06-22 Completed Date: 1977-06-22 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7503089 Medline TA: J Natl Cancer Inst Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1185-90 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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B-Lymphocytes
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immunology* Cell Membrane / immunology Complement System Proteins Female Hodgkin Disease / immunology Humans Immunity, Cellular Leukemia, Lymphoid / immunology* Leukocyte Count Lymphatic Diseases / immunology Lymphoma / immunology* Lymphoma, Large B-Cell, Diffuse / immunology Lymphoma, Non-Hodgkin / immunology Male Receptors, Antigen, B-Cell T-Lymphocytes / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Antigen, B-Cell; 9007-36-7/Complement System Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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