Document Detail

Immunologic abnormalities in patients with malignant lymphoproliferative diseases.
MedLine Citation:
PMID:  323504     Owner:  NLM     Status:  MEDLINE    
The B- and T-lymphocyte distribution was studied in 45 patients with malignant lymphoproliferative diseases. Eight patients with untreated Hodgkin's disease had normal mean percentages of complement receptor lymphocyte (CRL) cells and T-cells; however, the mean absolute number of T-cells was decreased. T-lymphocytes were also decreased in 3 patients with Hodgkin's disease treated 7-24 months previously. The number of T-lymphocytes increased markedly in all patients after treatment. Lymphocyte surface markers in non-Hodgkin's lymphoma showed distinctive patterns. Patients with leukemic reticuloendotheliosis or "hairy cell leukemia" characteristically had low percentages of CRL but normal or increased percentages of surface immunoglobulin-positive lymphocytes. The mean percentage and number of T-lymphocytes in this group were normal. Eight patients with nodular lymphocytic lymphoma and 2 patients with nodular lymphocytic-histiocytic lymphoma had normal mean numbers of CRL but decreased numbers of T-lymphocytes. Of 6 patients with diffuse lymphocytic lymphoma, 4 had elevated percentages and numbers of CRL. Despite low percentages, normal numbers of T-lymphocytes were found in 3 of these patients.
C P Hunter; H Tannenbaum; W H Churchill; W C Moloney; P H Schur
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the National Cancer Institute     Volume:  58     ISSN:  0027-8874     ISO Abbreviation:  J. Natl. Cancer Inst.     Publication Date:  1977 May 
Date Detail:
Created Date:  1977-06-22     Completed Date:  1977-06-22     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7503089     Medline TA:  J Natl Cancer Inst     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1185-90     Citation Subset:  IM    
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MeSH Terms
B-Lymphocytes / immunology*
Cell Membrane / immunology
Complement System Proteins
Hodgkin Disease / immunology
Immunity, Cellular
Leukemia, Lymphoid / immunology*
Leukocyte Count
Lymphatic Diseases / immunology
Lymphoma / immunology*
Lymphoma, Large B-Cell, Diffuse / immunology
Lymphoma, Non-Hodgkin / immunology
Receptors, Antigen, B-Cell
T-Lymphocytes / immunology*
Reg. No./Substance:
0/Receptors, Antigen, B-Cell; 9007-36-7/Complement System Proteins

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