Document Detail


Immunologic consequences of chemotherapy for acute myeloid leukemia.
MedLine Citation:
PMID:  23018569     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There are few data characterizing the immunologic consequences of chemotherapy for acute myeloid leukemia (AML) and almost nothing is known about the effects of chemotherapy in a pediatric AML cohort. We identified T-cell subsets, B-cell subsets, and used Enzyme-linked immunosorbent spot analyses to define the function of T cells and B cells in 7 pediatric patients with AML on chemotherapy. The data show that the effects of chemotherapy disproportionately target the B cell and depletion of B cells is associated with impaired responses to the inactivated influenza vaccine. Diminished T-cell numbers were also observed although the magnitude of the effect was less than what was seen for B cells. Furthermore, measures of T-cell function were largely intact. We conclude that humoral immunity is significantly affected by chemotherapy for AML.
Authors:
Anne Reilly; Leslie S Kersun; Eline Luning Prak; Jean Boyer; Kenyetta McDonald; Abbas F Jawad; Kathleen E Sullivan
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of pediatric hematology/oncology     Volume:  35     ISSN:  1536-3678     ISO Abbreviation:  J. Pediatr. Hematol. Oncol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-19     Completed Date:  2013-02-21     Revised Date:  2014-01-10    
Medline Journal Info:
Nlm Unique ID:  9505928     Medline TA:  J Pediatr Hematol Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  46-53     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
B-Lymphocyte Subsets / drug effects,  immunology*,  pathology
Case-Control Studies
Child
Cohort Studies
Female
Follow-Up Studies
Humans
Influenza Vaccines / administration & dosage
Influenza, Human / immunology,  prevention & control
Leukemia, Myeloid, Acute / drug therapy,  immunology*,  pathology
Male
T-Lymphocyte Subsets / drug effects,  immunology*,  pathology
Treatment Outcome
Grant Support
ID/Acronym/Agency:
N01-AI-50024/AI/NIAID NIH HHS; N01AI50024/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Influenza Vaccines
Comments/Corrections

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