| Immunologic abnormality of intrahepatic cholestasis of pregnancy. | |
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MedLine Citation:
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PMID: 20085564 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PROBLEM: Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy risk because of the possibility of pre-term delivery and sudden intrauterine fetal death. Its pathogenesis is still under discussion. METHOD OF STUDY: The analysis of the recent findings on the complex immunologic events that occur in ICP were performed. RESULTS: In ICP, an increase of type 1 cytokine (TNF-alpha, IFN-gamma) associated with a decrease of type 2 cytokine (IL-4). The decreased production of the suppressor cytokine TGF-beta2 may increase the type 1 cytokine. Fas appeared to be increased and FasL appeared to be decreased in syncytiotrophoblasts of ICP. The human leukocyte antigen gene (HLA-G, E) in extravillous trophoblasts of ICP were significantly decreased. CONCLUSION: Th1/Th2 cytokine balance and HLA play important roles in the tolerance and maintenance of pregnancy. ICP may be resulting from breach of the maternal fetal immune tolerance during pregnancy. |
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Authors:
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Hu Yayi; Wang Danqing; Liu Shuyun; Liu Jicheng |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-01-20 |
Journal Detail:
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Title: American journal of reproductive immunology (New York, N.Y. : 1989) Volume: 63 ISSN: 1600-0897 ISO Abbreviation: Am. J. Reprod. Immunol. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-06 Completed Date: 2010-04-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8912860 Medline TA: Am J Reprod Immunol Country: Denmark |
Other Details:
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Languages: eng Pagination: 267-73 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, The Second West China Hospital, Sichuan University, Chengdu, Sichuan, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cholestasis, Intrahepatic / complications, genetics, immunology* Cytokines / immunology Female HLA Antigens / genetics, immunology Humans Immune Tolerance Polymorphism, Genetic Pregnancy Pregnancy Complications / genetics, immunology*, pathology |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/HLA Antigens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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