Document Detail


Immunolocalization of progesterone receptors in bovine placentomes throughout mid and late gestation and at parturition.
MedLine Citation:
PMID:  10456859     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The corpus luteum is the main source of progesterone (P(4)) responsible for maintenance of gestation in cattle. So far it has not been possible to assign any biological role to placental P(4), which contributes only marginally and temporarily to peripheral maternal blood levels. In order to identify possible P(4) target cells within the placenta, placentomes from 150-, 220-, 240-, and 270-day-pregnant cows and from parturient cows (3 animals per group) were screened immunohistochemically for expression of the progesterone receptor (PR). During gestation, PR-positive staining was found exclusively in the nuclei of caruncular stromal cells (CSC; maternal part of the placentome) and of caruncular vascular pericytes. In placentomes from parturient cows, occasional positive nuclear staining was also observed in the walls of small caruncular arteries. The percentage of PR-positive CSC increased slightly from 51.8 +/- 2.6% on Day 150 to 56.2 +/- 5.6% at Day 270 (p < 0.05) and was 58.9 +/- 1.8% at parturition. These results suggest that in pregnant cattle, CSC are under the control of P(4) of placental rather than luteal origin. Thus, whereas luteal P(4) may regulate "coarse" systemic progestational functions in the maternal compartment in the classical hormonal manner, placental P(4) may act as a paracrine factor involved in the local regulation of caruncular growth, differentiation, and functions.
Authors:
G Schuler; C Wirth; K Klisch; C Pfarrer; R Leiser; B Hoffmann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biology of reproduction     Volume:  61     ISSN:  0006-3363     ISO Abbreviation:  Biol. Reprod.     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-09-20     Completed Date:  1999-09-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0207224     Medline TA:  Biol Reprod     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  797-801     Citation Subset:  IM    
Affiliation:
Klinik für Geburtshilfe, Gynäkologie und Andrologie der Grobeta- und Kleintiere mit Tierärztlicher Ambulanz, Justus-Liebig-Universität, D-35392 Giessen, Germany. gerhard.schuler@vetmed.uni-giessen.de
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MeSH Terms
Descriptor/Qualifier:
Animals
Cattle*
Cell Nucleus / chemistry
Female
Gestational Age*
Immunohistochemistry
Labor, Obstetric*
Placenta / chemistry*
Pregnancy
Progesterone / physiology
Receptors, Progesterone / analysis*
Stromal Cells / ultrastructure
Chemical
Reg. No./Substance:
0/Receptors, Progesterone; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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