Document Detail

Immunolocalization of heat shock proteins 27 and 47 during repair of induced oral ulcers.
MedLine Citation:
PMID:  21206166     Owner:  NLM     Status:  MEDLINE    
Heat shock proteins (Hsps) 27 and 47 are involved in the control of apoptosis, cell migration, and collagen synthesis. There is some understanding of the immunolocalization of these proteins during the repair process in skin and gastrointestinal mucosa, but their expressions in normal and injured oral mucosa are unknown. The aim of this study was to analyze the immunolocalization and intensity of these proteins in oral ulcers induced in rats and to compare these expression levels with those reported in skin and gastric mucosa. Ulcers were induced on the ventral surface of the tongues of rats. The rats were then euthanized at 0, 24, 48, 72, and 120 h. Hsp27 expression remained low in the first hours of repair, but was higher at 72 h, mainly in the migrating epithelium. Expression of Hsp47 was high at 48 h, mainly in fibroblasts, cells of the vascular wall, and basal keratinocytes of migrating epithelium. In the control group, expressions of these proteins were low, which indicates that these Hsps are constitutive proteins in oral mucosa. Expression levels were similar to those reported in the healing of skin lesions and gastric ulcer, suggesting a common mechanism of Hsp activation in the repair of these tissues.
Mayra T Vasques; Marco Aurélio V Alves; João G de Cerqueira Luz; Luciana Corrêa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of oral science     Volume:  52     ISSN:  1880-4926     ISO Abbreviation:  J Oral Sci     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2011-01-05     Completed Date:  2011-04-25     Revised Date:  2011-11-03    
Medline Journal Info:
Nlm Unique ID:  9808942     Medline TA:  J Oral Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  623-31     Citation Subset:  D; IM    
Oral Pathology Department, School of Dentistry, University of São Paulo, Brazil.
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MeSH Terms
HSP27 Heat-Shock Proteins / analysis*
HSP47 Heat-Shock Proteins / analysis*
Immunoenzyme Techniques
Mouth Mucosa / chemistry,  metabolism*
Oral Ulcer / metabolism*
Random Allocation
Rats, Wistar
Skin Ulcer / metabolism
Stomach Ulcer / metabolism
Tongue Diseases / metabolism
Wound Healing / physiology*
Reg. No./Substance:
0/HSP27 Heat-Shock Proteins; 0/HSP47 Heat-Shock Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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