Document Detail

Immunolocalization of c-Fos and c-Jun in human oral mucosa and in oral squamous cell carcinoma.
MedLine Citation:
PMID:  11896827     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Studies have addressed the relevance of c-Jun and c-Fos proteins in cancer development. In the present study, the expression of c-Jun and c-Fos, the major components of transcription factor activator protein (AP1), were evaluated to determine possible alterations to these factors in oral squamous cell carcinoma (OSCC). METHODS: Fifteen cases of normal oral mucosa and 20 cases of OSCC were retrieved from the Archives of the Surgical Pathology Service at the University of São Paulo. The samples of normal oral mucosa or OSCC originated from different oral mucosal sites. Tissues were submitted for immunohistochemical analysis to detect c-Jun and c-Fos proteins. The OSCC was classified as well, intermediate or poorly differentiated. RESULTS: The results showed that both c-Jun and c-Fos are expressed in normal oral mucosa and in OSCC. In normal mucosa, immunoreactivity for c-Jun was detected in the cytoplasm of the upper basal layers, while in OSCC, c-Jun was detected in the nuclei of the cells. C-Fos expression was observed in the nuclei of cells, both in normal mucosa and in OSCC, but its expression varied according to the cell layer in normal mucosa, and the differentiation of OSCC. CONCLUSIONS: The nuclear expression of c-Jun in OSCC, in contrast to its cytoplasmic expression in normal oral mucosa, indicates that c-Jun may have a role in the development of oral cancer. In contrast, the absence of both c-Jun and c-Fos in poorly differentiated carcinoma might be useful in understanding the cell cycle events important in uncontrolled cell growth.
Suzana Orsini Machado de Sousa; Ricardo Alves Mesquita; Décio Santos Pinto; Silvio Gutkind
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology     Volume:  31     ISSN:  0904-2512     ISO Abbreviation:  J. Oral Pathol. Med.     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-03-18     Completed Date:  2002-07-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8911934     Medline TA:  J Oral Pathol Med     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  78-81     Citation Subset:  D; IM    
Department of Oral Pathology, University of São Paulo, School of Dentistry, São Paulo, Brazil.
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MeSH Terms
Carcinoma, Squamous Cell / chemistry,  metabolism*
Cell Nucleus / chemistry,  metabolism
Gene Expression Regulation, Neoplastic
Mouth Mucosa / metabolism*
Mouth Neoplasms / chemistry,  metabolism*
Proto-Oncogene Proteins c-fos / analysis,  metabolism*
Proto-Oncogene Proteins c-jun / analysis,  metabolism*
Transcription Factor AP-1 / metabolism
Reg. No./Substance:
0/Proto-Oncogene Proteins c-fos; 0/Proto-Oncogene Proteins c-jun; 0/Transcription Factor AP-1

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