Document Detail

Immunolocalization of c-Fos and c-Jun in rat ocular surface epithelium.
MedLine Citation:
PMID:  10657749     Owner:  NLM     Status:  MEDLINE    
We immunohistochemically located c-Fos and c-Jun, the major components of transcription factor activator protein 1 (AP1), in normal epithelia of rat cornea and conjunctiva to determine the expression of these genes in the ocular surface epithelia. Immunoreactivity for c-Fos was detected in the nuclei of basal cells of the limbal and conjunctival epithelia, while that for c-Jun was detected in the cytoplasm of the cells of these epithelia. The corneal epithelium lacked immunoreactivity for either protein. AP1 may have an important role in the maintenance of homeostasis of limbal and conjunctival epithelia.
S Saika; Y Okada; K Shirai; Y Kawashima; O Yamanaka; Y Ohnishi; A Ooshima
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ophthalmic research     Volume:  32     ISSN:  0030-3747     ISO Abbreviation:  Ophthalmic Res.     Publication Date:    2000 Jan-Feb
Date Detail:
Created Date:  2000-04-07     Completed Date:  2000-04-07     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0267442     Medline TA:  Ophthalmic Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  9-12     Citation Subset:  IM    
Copyright Information:
Copyright 2000 S. Karger AG, Basel.
Department of Ophthalmology, Wakayama Medical College, Wakayama, Japan.
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MeSH Terms
Conjunctiva / chemistry*
Epithelial Cells / chemistry*
Epithelium, Corneal / chemistry*
Immunoenzyme Techniques
Limbus Corneae / chemistry
Proto-Oncogene Proteins c-fos / analysis*
Proto-Oncogene Proteins c-jun / analysis*
Rats, Wistar
Reg. No./Substance:
0/Proto-Oncogene Proteins c-fos; 0/Proto-Oncogene Proteins c-jun

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