Document Detail

Immunohistopathology of Sjögren's syndrome.
MedLine Citation:
PMID:  17110311     Owner:  NLM     Status:  MEDLINE    
Sjögren's syndrome (SS) is characterized by keratoconjunctivitis sicca and xerostomia, which occur in an autoimmune lacrimal and salivary gland disease characterized by lymphocyte infiltrates of exocrine glands and/or Sjögren's syndrome autoantibody production. It has been reported that aquaporin-5 distribution is abnormal in SS, perhaps as a result of paracrine effect of TNF-alpha. Also the neurogenic regulation of the salivary gland is impaired in SS. Apart from functional changes, the syndrome is also characterized by structural abnormalities of the secretory acinar apparatus. The acinar basement membrane is abnormal as it lacks laminin alpha1 chain, which may impair its capability to induce the progenitor cells to differentiate to acinar cells. CRISP-3 and TMPRSS-2 can be used as androgen markers and LIV-1 and Cyr61 as estrogen markers to study the sexual dimorphism of the salivary glands. Patients with SS seem to have low concentrations of dehydroepiandrosterone, which may predispose women and the exocrine glands to this syndrome.
Yrjö T Konttinen; Pauliina Porola; Liisa Konttinen; Mikael Laine; Praseet Poduval
Publication Detail:
Type:  Journal Article; Review     Date:  2006-04-19
Journal Detail:
Title:  Autoimmunity reviews     Volume:  6     ISSN:  1568-9972     ISO Abbreviation:  Autoimmun Rev     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-11-19     Completed Date:  2007-02-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101128967     Medline TA:  Autoimmun Rev     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  16-20     Citation Subset:  IM    
Department of Medicine, FIN-00029 HUS, Finland.
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MeSH Terms
Basement Membrane / metabolism,  pathology
Membrane Proteins*
Salivary Glands / cytology,  pathology*
Sjogren's Syndrome / immunology,  pathology*,  physiopathology
Reg. No./Substance:
0/Membrane Proteins

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