Document Detail

Immunohistologic evidence that villitis in human normal term placentas is an immunologic lesion.
MedLine Citation:
PMID:  2137969     Owner:  NLM     Status:  MEDLINE    
Villitis of unestablished origin is a lesion in placentas from normal and high-risk pregnancies. We have studied villitis areas in 25 normal term placentas for immune cells, coagulation components, and endothelial markers. Villitis areas were filled with activated (HLA-DR, HLA-DP, and HLA-DQ reactive) macrophages. B lymphocytes were not identified, and T lymphocytes were of the helper (CD4) phenotype. Antibodies to coagulation components revealed perivascular and trophoblastic basement membrane deposits of factor IX, increased numbers of platelets, and fetal stem vessels that did not react with endothelial markers. These findings suggest helper T lymphocytes activate macrophages that mediate coagulation activation and alter endothelium. This combination of immunologic events results in tissue changes that are histologically diagnosed as villitis. It is not known what triggers these immunologic events, but the finding of villitis in normal placentas suggests the causative factor(s) is present in all pregnancies.
C A Labarrere; J A McIntyre; W P Faulk
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  162     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-04-05     Completed Date:  1990-04-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  515-22     Citation Subset:  AIM; IM    
Center for Reproduction and Transplantation Immunology, Methodist Hospital of Indiana, Indianapolis 46202.
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MeSH Terms
Blood Coagulation
Chorionic Villi* / immunology,  pathology
Endothelium, Vascular / immunology
HLA-DR Antigens / analysis
Inflammation / immunology
Macrophages / immunology
Placenta Diseases / immunology*
T-Lymphocytes, Helper-Inducer / immunology
Reg. No./Substance:
0/HLA-DR Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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