Document Detail

Immunohistologic diagnosis of systemic mycoses: an update.
MedLine Citation:
PMID:  1397200     Owner:  NLM     Status:  MEDLINE    
Fluorescent antibody, immunoperoxidase and gold-silver staining methods for the rapid and accurate diagnosis of systemic mycotic infections are currently performed in a few specialized laboratories. These methods have proved applicable to formalin-fixed, paraffin-embedded tissues, and are reliable for identifying therein antigens of infectious dimorphic, monomorphic filamentous, and yeast-like fungal pathogens, i.e., Aspergillus spp., Blastomyces dermatitidis, Candida spp., Coccidioides immitis, Cryptococcus neoformans, Fusarium spp., Histoplasma capsulatum, Paracoccidioides brasiliensis, Pseudallescheria boydii, and Sporothrix schenckii. Most of the available reagents are derived from multiple adsorbed polyclonal antisera. However, problems occur in the production of uniform and standardized species- or genus- specific antibodies. Monoclonal antibodies, although promising, have to date not eliminated these problems. Immunohistologic methods will become more routinely used in clinical laboratories as these problems are resolved and more sensitive and specific reagents become commercially available.
L Kaufman
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  European journal of epidemiology     Volume:  8     ISSN:  0393-2990     ISO Abbreviation:  Eur. J. Epidemiol.     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-10-26     Completed Date:  1992-10-26     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8508062     Medline TA:  Eur J Epidemiol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  377-82     Citation Subset:  IM    
Mycotic Diseases Branch, Centers for Disease Control, Atlanta, Georgia 30333.
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MeSH Terms
Antibodies, Fungal / analysis
Antibodies, Monoclonal
Antigens, Fungal / immunology
Fluorescent Antibody Technique
Immunoenzyme Techniques
Mycoses / diagnosis*,  immunology
Reg. No./Substance:
0/Antibodies, Fungal; 0/Antibodies, Monoclonal; 0/Antigens, Fungal

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