| Immunohistochemistry of p63 in primary and secondary vulvar Paget's disease. | |
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MedLine Citation:
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PMID: 18801085 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Vulvar Paget's disease (VPD) is classified into primary and secondary types. Differentiation of these subsets in biopsy specimen is important for appropriate therapy. Expression profile of cytokeratin (CK) 7 and CK20, gross cystic disease fluid protein-15 and uroplakin III has been reported as a differentiation marker of primary and secondary VPD. To examine the role of p63 immunostaining in differential diagnosis between primary VPD and VPD secondary to urothelial carcinoma (VPD-UC), expression of p63 was examined in nine cases of VPD. Paget cells in seven cases of VPD without UC did not express p63. In two cases of VPD associated with UC, Paget cells and UC cells had identical CK expression profile. UC cells were positive for p63 in both cases. In one case, Paget cells were positive for p63 and examination of the resected specimen showed that VPD was secondary to UC. In another case, Paget cells were negative for p63 and this was diagnosed as primary VPD independent of UC. This indicates that p63 is absent in Paget cells in primary VPD and is therefore useful in differentiating primary VPD from VPD-UC. |
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Authors:
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Hiroyuki Yanai; Narihisa Takahashi; Masako Omori; Wakako Oda; Ichiro Yamadori; Shin-ichi Takada; Hiroo Matsuura; Tadashi Yoshino |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pathology international Volume: 58 ISSN: 1440-1827 ISO Abbreviation: Pathol. Int. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-09-19 Completed Date: 2008-10-30 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9431380 Medline TA: Pathol Int Country: Australia |
Other Details:
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Languages: eng Pagination: 648-51 Citation Subset: IM |
Affiliation:
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Department of Pathology, Okayama University Hospital, Okayama, Japan. yanaih@md.okayama-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Diagnosis, Differential Female Humans Immunohistochemistry Keratin-20 / metabolism Keratin-7 / metabolism Middle Aged Paget Disease Extramammary / classification, metabolism*, secondary Trans-Activators / metabolism* Tumor Markers, Biological / metabolism Tumor Suppressor Proteins / metabolism* Urinary Bladder Neoplasms / metabolism*, pathology Vulva / pathology, surgery Vulvar Neoplasms / classification, metabolism*, pathology |
| Chemical | |
Reg. No./Substance:
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0/Keratin-20; 0/Keratin-7; 0/TP63 protein, human; 0/Trans-Activators; 0/Tumor Markers, Biological; 0/Tumor Suppressor Proteins |
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