Document Detail


Immunohistochemistry of melanocytic proliferations.
MedLine Citation:
PMID:  21732774     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Abstract Context.-Histologic analysis allows accurate classification of most melanocytic lesions as benign or malignant. Only in a minority of lesions is it necessary to use other techniques as an aid in the diagnosis. Among them, most authors recommend immunohistochemistry. Objective.-To describe how to apply immunohistochemistry to particular differential diagnoses and the potential pitfalls. Data Sources.-Personal experience and review of literature. Conclusions.-here is no single marker, or combination thereof, that establishes an unequivocal diagnosis of melanoma or nevus. Thus it is necessary to carefully analyze the pattern of expression (patchy versus diffuse) and localization (maturation) in the context of morphologic standard features.
Authors:
Victor G Prieto; Christopher R Shea
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of pathology & laboratory medicine     Volume:  135     ISSN:  1543-2165     ISO Abbreviation:  Arch. Pathol. Lab. Med.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-07-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7607091     Medline TA:  Arch Pathol Lab Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  853-9     Citation Subset:  AIM; IM    
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