| Immunohistochemistry, glycosylation and immunosuppression of glycodelin in human ovarian cancer. | |
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MedLine Citation:
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PMID: 18853174 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Glycodelins (Gds) are glycoproteins with a gender specific glycosylation. Glycodelin A (GdA) is primarily produced in endometrial and decidual tissue and secreted to amniotic fluid. Glycodelins were also identified in several cancer types, including serous ovarian cancer. Gds act as a T-cell inhibitor and are involved in inactivation of human monocytes. With a Gd peptide antibody, derived from a 15 amino acid sequence of human Gd and in situ hybridization experiments, the expression of Gd in serous, mucinous, endometrioid and clear cell ovarian tumors was identified. In contrast to former investigations with antibodies against GdA, a positive immunohistochemical reaction for Gd was observed in all forms of epithelium ovarian cancer. These results were confirmed with in situ hybridization. In addition, Gd is expressed in granulose cell tumors, a non-epithelial form of ovarian cancer. Furthermore, Gd was purified from ascites fluid of ovarian cancer patients. Ascites Gd showed significant differences in its structure of sialyl Lewis-type oligosaccharides compared to GdA. Additionally, ascites Gd inhibits IL-2 stimulated proliferation of peripheral blood leucocytes and inhibits adhesion of SLe(X)-positive cells to E-selectin. Therefore, Gd could act as an inhibitor of lymphocyte activation and/or adhesion in ovarian cancer. |
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Authors:
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Udo Jeschke; Ioannis Mylonas; Christiane Kunert-Keil; Renate Stahn; Christoph Scholz; Wolfgang Janni; Christina Kuhn; Eike Schröder; Doris Mayr; Klaus Friese |
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Publication Detail:
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Type: Journal Article Date: 2008-10-14 |
Journal Detail:
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Title: Histochemistry and cell biology Volume: 131 ISSN: 1432-119X ISO Abbreviation: Histochem. Cell Biol. Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-01-08 Completed Date: 2009-04-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9506663 Medline TA: Histochem Cell Biol Country: Germany |
Other Details:
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Languages: eng Pagination: 283-95 Citation Subset: IM |
Affiliation:
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Ist Department of Obstetrics and Gynecology, Ludwig-Maximilians-University of Munich, Maistrasse 11, 80337, Munich, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Adhesion
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drug effects Female Glycoproteins / analysis*, chemistry, immunology Glycosylation Humans Immunohistochemistry Immunosuppression Lymphocyte Activation / drug effects Oligosaccharides / chemistry Ovarian Neoplasms / chemistry*, immunology Pregnancy Proteins / analysis*, chemistry, immunology |
| Chemical | |
Reg. No./Substance:
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0/5-acetylneuraminyl-(2-3)-galactosyl-(1-4)-(fucopyranosyl-(1-3))-N-acetylglucosamine; 0/Glycoproteins; 0/Oligosaccharides; 0/PAEP protein, human; 0/Pregnancy Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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