Document Detail


Immunohistochemistry of diazepam binding inhibitor (DBI) in the central nervous system and peripheral organs: its possible role as an endogenous regulator of different types of benzodiazepine receptors.
MedLine Citation:
PMID:  1664066     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The distribution of diazepam binding inhibitor (DBI), a multi-function peptide which has recently been discovered, was studied in the rat and human central nervous system and in peripheral organs of the rat by light and electron microscopical immunohistochemistry. In the central nervous system, DBI-LI was localized in many glial cells and glial tumors, and in some neurons. In the periphery, DBI-LI was found in many tissues but it was expressed selectively in specialized cell types. Intense DBI-LI was observed in some endocrine, steroid-producing cells such as glomerular cells of the adrenal gland and Leydig cells of the of the testis. Different types of epithelial cells, for instance distal convoluted tabular cells of the kidney and mucosal cells of the small intestine, displayed moderate DBI-LI. Some supporting cells, such as Schwann cells and Sertoli cells, were also immunopositive. The frequent localization of DBI in cells, also known to contain large amounts of mitochondrial benzodiazepine receptors, indicates that DBI may play an important role as an endogenous regulator of intracellular metabolic functions via the mitochondrial benzodiazepine receptor.
Authors:
H Alho; T Harjuntausta; R Schultz; M Pelto-Huikko; P Bovolin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuropharmacology     Volume:  30     ISSN:  0028-3908     ISO Abbreviation:  Neuropharmacology     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1992-03-10     Completed Date:  1992-03-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0236217     Medline TA:  Neuropharmacology     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1381-6     Citation Subset:  IM    
Affiliation:
Department of Biomedical Sciences, University of Tampere, Finland.
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MeSH Terms
Descriptor/Qualifier:
Adrenal Glands / cytology
Amygdala / cytology
Animals
Astrocytes / cytology*
Brain / cytology*
Cerebral Cortex / cytology
Diazepam Binding Inhibitor
Homeostasis
Humans
Immunoenzyme Techniques
Immunohistochemistry / methods
Intestines / cytology
Kidney / cytology
Liver / cytology
Lung / cytology
Male
Microscopy, Immunoelectron / methods
Myocardium / cytology
Neuropeptides / analysis,  physiology*
Rats
Rats, Inbred Strains
Receptors, GABA-A / physiology*
Testis / cytology
Chemical
Reg. No./Substance:
0/Diazepam Binding Inhibitor; 0/Neuropeptides; 0/Receptors, GABA-A

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