| Immunohistochemical study of stellate cells in patients with chronic viral hepatitis C genotype 1. | |
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MedLine Citation:
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PMID: 21424045 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Introduction: Hepatic stellate cells (HSC) are key-players in the pathogenesis of liver fibrosis, inducing collagen deposition and abnormal extracellular matrix remodeling. Aim: The purpose of this study was to identify the stellate cells using immunohistochemical techniques and to establish if there is a correlation between the expression of stellate cells and the clinical and histological parameters in patients with chronic viral hepatitis C. Materials and Methods: The studied group included 30 patients with chronic viral hepatitis C genotype 1, in whom a liver biopsy was performed previous to the antiviral treatment. After the histological analyze, the biopsy was stained with an anti-SMA antibody (Dako, Carpinteria, CA). The amount of positive stained area was determined using an arbitrary semiquantitative score from 1 to 4. Results: Our observations suggest that there is a strong correlation between the stellate cells activity, evaluated using a semiquantitative score, and the stage of liver fibrosis (rs=0.76, p<0.001). Also, our study revealed a direct correlation, but less intense, with the necro-inflammatory activity (rs=0.39, p=0.03), the steatosis degree (rs=0.428, p=0.01) and the value of alanine aminotransferase (rs=0.4, p=0.03). The age and the viremia level were not correlated with the activity of the stellate cells. Conclusions: This study suggests that the transition of stellate cells from inactivated state to the state of highly fibrogenic cell is influenced mainly by the histological liver modifications (necroinflammatory activity and steatosis) and less by clinical parameters (age, sex) or the viremia level. |
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Authors:
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Larisa Săndulescu; I Rogoveanu; T Ciurea; Maria Victoria Comănescu; C T Streba; A G Ionescu; Alice Oproaica; M Ene |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie Volume: 52 ISSN: 1220-0522 ISO Abbreviation: Rom J Morphol Embryol Publication Date: 2011 |
Date Detail:
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Created Date: 2011-03-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9112454 Medline TA: Rom J Morphol Embryol Country: Romania |
Other Details:
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Languages: eng Pagination: 137-43 Citation Subset: IM |
Affiliation:
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Research Centre in Gastroenterology and Hepatology, Craiova, Romania; larisasandulescu@yahoo.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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